Author/Editor		Strle, Franc; Nadelman, Robert B; Cimperman, Jože; Nowakowski, John; Picken, Roger N; Schwartz, Ira; Maraspin, Vera; Aguero-Rosenfeld, Maria E; Varde, Shobha; Lotrič-Furlan, Stanka; Wormser, Gary P
Title		Comparison of culture-confirmed erythema mirgans casued by Borrelia burgdorferi sensu stricto in New York state and by Borrelia afzelii in Slovenia
Type		članek
Source		Ann Intern Med
Vol. and No.		Letnik 130, št. 1
Publication year		1999
Volume		str. 32-6
Language		eng
Abstract		Background: The clinical manifestations of Lyme borreliosis in North America and Europe seem to differ, but a systematic comparison has never been done. Objective: To compare European and U.S. patients with culture-confirmed erythema migrans. Design: Prospective, clinical cohort study. Setting: University medical centers in Westchester Country, New York, amd Ljubljana, Slovenia. Patients: 110 U.S. patients with Borrelia burgdorferi sensu stricto infection and 85 Slovenian patients with B. afzelii infection. Measurements: Interview, physical examination, and laboratory assays. Results: Compared with Slovenian patients, U.S. patients had erythema migrans for a briefer duration (median duration, 4 days compared with 14 days: P < 0.001) but were more likely to have systemic symptoms )P = 0.01), abnormal findings on physical examination (P < 0.001), and seroreactivity (P < 0.001). Central clearing of erythema migrans lesions was more likely in Slovenian patients (P < 0.001). Conclusions: Erythema migrans caused by B. afzelii in Slovenia and erythema migrans acused by B. burgdorferi in New York have distinct clinical presentations. Caution should be used when clinical laboratory experience from one side of the Atlantic is applied to pateints on the other.
Descriptors		ERYTHEMA CHRONICUM MIGRANS BORRELIA BORRELIA BURGDORFERI MEDICAL HISTORY TAKING PHYSICAL EXAMINATION NEW YORK SLOVENIA COHORT STUDIES POLYMERASE CHAIN REACTION IGG IGM