Author/Editor		Denišlič, Miro
Title		Multipla skleroza in druge demielinizacijske bolezni
Translated title		Multiple sclerosis and other demyelinating diseases
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 37, št. Suppl 4
Publication year		1998
Volume		str. 317-25
Language		slo
Abstract		At the beginning the author highlights the distrihution of multiple sclerosis and emphasizes the roles of geographic region, gender and genetic factors which influence its development. Slovenia, as a Central European, bears a high risk for demyelinating diseases. Regarding pathology, the author provides the recent findings of early axonal damage in demyelinating lesions. He further describes the main clinical symptoms and signs particularly the so-called definite signs, as well as laboratory tests and neuroimaging techniques. The clinical picture and laboratory procedures in childhood are demonstrated. Other demyelinating diseases occurring in childhood are briefly described. Finally, the criteria for selection of patients and the treatment of relapse-remitting multiple sclerosis are discussed.
Summary		Avtor v prispevku najprej osvetli problem razširjenosti multiple skleroze. Poudari pomen zemljepisne širine, spola in genetskih dejavnikov na razvoj bolezni. Glede na zemljepisno lego sodi Slovenija na področje, kjer je bolezen močno razširjena. Predstavi nove poglede na pomen aksonske okvare za razvoj bolezenskih znakov že v začetku bolezni. Opiše glavne klinične simptome in znake bolezni, poudari pa predvsem zanesljive. Prikaže laboratorijske in slikovite metode, ki jih uporabljamo v diagnostiki multiple skleroze. Posebej oriše klinične in laboratorijske značilnosti bolezni v otroški dobi. Opozori na bolezni, ki lahko pri magnetno-resonančnem slikanju povzročijo v možganski beli snovi podobne spremembe, kot so opisane pri multipli sklerozi. Predstavi tudi nove možnosti zdravljenja recidivno-remitentne multiple skleroze in merila za izbor bolnikov.
Descriptors		MULTIPLE SCLEROSIS DEMYELINATING DISEASES CHILD