Author/Editor     Serša, Gregor; Beravs, Katarina; Čemažar, Maja; Miklavčič, Damijan; Demšar, Franci
Title     Contrast enhanced MRI assessment of tumor blood volume after application of electric pulses
Type     članek
Source     Electro Magnetobiol
Vol. and No.     Letnik 17, št. 2
Publication year     1998
Volume     str. 299-306
Language     eng
Abstract     The effect of application of short, intense electric pulses on tumor blood volume was investigated using albumin-(Gd-DTPA)30 contrast enhanced magnetic resonance imaging (MRI). One of paired SA-1 fibrosarcoma tumorsimplanted in each flank of A/J mice was treated electric pulses. MRI was performed dynamically before and after intravenous administration of albumin-(Gd-DTPA)30(0.02mmol Gd/kg), and fractional tumor blood volume was estimated. MRI images of tumors exposed to electric pulses showed no enhancement at 30 min after injection of albumin-(Gd-DTPA)30. However, marked enhancement was observed in paired tumors of the same mice that were not exposed to electric pulses. A significant difference in blood volume was observed between nontreated tumors and tumors treated with electric pulses. Application of electric pulses to the tumors significantly reduced blood volume in the tumors. Therefore, through a reduction in tumor blood volume, electric pulses may, besides producing electroporation of cells, exert anitumor effectiveness by entrapping drugs within the tumors.
Descriptors     SARCOMA, EXPERIMENTAL
MAGNETIC RESONANCE IMAGING
ELECTROMAGNETIC FIELDS
MICE, INBRED STRAINS
CONTRAST MEDIA
GADOLINIUM
DTPA