Author/Editor     Reberšek-Gorišek, Jelka; Novak, Zmago
Title     Zvišana telesna temperatura pri okužbah
Translated title     Fever in infections
Type     članek
Source     Med Razgl
Vol. and No.     Letnik 38, št. Suppl 1
Publication year     1999
Volume     str. 1-6
Language     slo
Abstract     Fever is an elevation of body temperature due to disturbances in the thermoregulatory centre. Infection is often the cause. In humans the themoregulatory centre is the preoptic area of the hypothalamus acting as a thermostat and ensuring constant body temperature determined by the set-point. The elevation of body temperature occurs due to a change of the set-point to a higher value. Fever is mostly induced by endogenous pyorgens also called pyorgenic cytokines. They are produced b the human organism as a response are usually microblal products, toxins or microbes themselves. Pyorgenic cytokines cause fever by means of biochemical changes in the hypothalamus. Here the stimulation of prostoglandin synthesis, resulting in a rise of the set-point, is of particular importance. The essence of fever therapy in infections is the treatment of the ineffective agent.
Summary     Zvišana telesna temperatura je dvig telesne temperature zaradi motnje v delovanju termoregulacijskega centra. Pogosto so vzrok okužbe. Center za uravnavanje telesne temperature pri človeku je preoptični predel hipotalamusa, ki deluje kot termostat in zagotavlja stalno telesno temperaturo, ki je določena s točko nastavitve. Porast telesne temperature nastane zaradi spremembe točke nastavitve na višjo vrednost. Večinoma zvišano telesno temperaturo povzročijo endogeni pirogeni, imenovani tudi pirogeni citokini. Le-te proizvaja človeški organizem kot odgovor na eksogene pirogene, ki prihajajo v naš organizem od zunaj. Običajno so eksogeni pirogeni mikrobni produkti, toksini ali mikrobi sami. Pirogeni citokini povzročajo zvišano telesno tempeaturo s pomočjo biokemičnih sprememb v hipotalamusu. Pri tem je posebej pomembna stimulacija sinteze prostaglandinov, ki povzročajo dvig točke nastavitve. Bistvo zdravljenja zvišane telesne temperature pri okužbah je zdravljenje povzročitelja okužbe.
Descriptors     FEVER
INFECTION
PYROGENS