Author/Editor		Komel, Radovan
Title		Oncogenes and tumor suppressor genes
Type		članek
Source		In: Osmak M, Škrk J, editors. Molecular oncology today. Proceedings of the Croatian-Slovenian meeting; 1995 Dec 19; Zagreb. Zagreb: Croatian ligue against cancer,
Publication year		1996
Volume		str. 5-9
Language		eng
Abstract		Cancerous tumors are made up of cells that grow out of control because they have defects that involve one or more proteins responsible for cell division regulation. Proto-oncogenes are normal human genes that generally encode proteins involved in normal cell division, growth and development. They include genes for tyrosine kinases, growth factors and their receptors, and G-proteins - all of them being proteins which participate in normal growth-control signaling. Some other proto-oncogenes encode nuclear proteins that are involved in gene regulation. Dominant events causing overexpression and/or enhanced activity of their protein products transform proto-oncogenes to oncogenes. On the other hand, mutations in both copies of anti-oncogenes (named recessive oncogenes or tumor suppressor genes, normally functioning to arrest the cell growth) eliminate or inactivate their protein products which normally suppress the cell growth stimulating proteins or their expression.
Descriptors		ONCOGENES GENES, SUPPRESSOR, TUMOR PROTO-ONCOGENES GROWTH SUBSTANCES SIGNAL TRANSDUCTION TRANSCRIPTION FACTORS GENE EXPRESSION