Author/Editor		Jan, Janja
Title		Vpliv polikloriranih bifenilov na razvojne okvare sklenine
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1998
Volume		str. 51
Language		slo
Abstract		Polychlorinated biophenyls (PCBs) are ubiquitous environmental pollutants and are current constituents of the human body. Serious contamination with PCBSs occurred in Bela krajina (Slovenia). So far no data is available on the effects of long-term exposure to PCBs on developmental defects of enamel. The aim of this study was to evaluate the effects of long-term exposure to PCBs on developmnetal defects in dental enamel. 202 8-14 year-old children who were pre- and post-natally exposed to PCBs in the contaminated region of Bela Krajina, Slovenia, were studied. 202 controls from Bršljin were matched for age and sex. Risk assessment was based on the concentrations of toxic PCB congeners in tissues and diet (expressed in total toxic equivalents of 2,3,7,8-TCDD), and the duration of exposure. The prevalence of developmental defects of enamel was assessed using the FDI Index. The data were analysed using the SPSS 6.0 statistical software package. PCB levels in different samples were analysed by high resolution gas chromatography (HRGC). Developmental defects of enamel in permanent teeth were found in 71.3% of exposed children, compared to 49.5% in the control group. The enamel was abnormal in 21.9% of the permanent index teeth of exposed children and in 12.7% of the control children. The difference was statistically significant hi2 = 84.2; p <- 0.001), mostly on account of demarcated opacities and hypoplasia. The extent of the defects was also greater in the exposed group (hi2 = 61.3; p <= 0.000). No significant correlations were found between PCB-exposure and developmental defects in deciduous teeth.(Abstract truncated at 2000 characters)
Descriptors		POLYCHLORINATED BIPHENYLS OCCUPATIONAL EXPOSURE DENTAL ENAMEL CHILD DENTIN CHROMATOGRAPHY, HIGH PRESSURE LIQUID FOOD CONTAMINATION