Author/Editor		Scherberger, Hansjoerg; Leder, Ortwin
Title		A planar model of hepatic blood flow potential
Type		članek
Source		Acta Stereol
Vol. and No.		Letnik 17, št. 3
Publication year		1998
Volume		str. 343-52
Language		eng
Abstract		We present a two-dimensional model of hepatic blood flow potential that takes afferent and efferent venous vessels and the sinusoidal capillary network into account. Congrucnt equilateral triangles were chosen as units. Planar patterns of such triangles. can be interpreted in terms of the classical hexagonal liver lobule, a complementary bile lobule, and of Rappaport's acinus. Model assumptions include a fixed terminal portal and hepatic venous pressure and a fixed distribution of flow conductivity inside the planar unit. Simulated pressure potentials differed substantially for the physiologic condition and for liver congestion. The model corresponds to the planar distribution of glucose-6-phosphatase activity and demonstrates an intimate relationship between hepatic microcirculation and metabolic heterogeneity. Furthermore, in simulations of liver congestion, predicted alterations of intralobular pressure reflected changes of liver morphology, thus suggesting a causal association between both processes.
Descriptors		LIVER HEPATIC VEINS MODELS, THEORETICAL