Author/Editor		Moravec-Berger, Daša; Stare, Janez; Šošić, Zvonko; Florjančič, Mojca
Title		Povezanost med dejavniki tveganja in prevalenco klinično očitne ateroskleroze pri 3781 prebivalcih Slovenije
Translated title		Relation between risk factors and prevalence of clinically manifest atherosclerosis in 3781 inhabitants of Slovenia
Type		članek
Source		Zdrav Vars
Vol. and No.		Letnik 37, št. 11-12
Publication year		1998
Volume		str. 455-60
Language		slo
Abstract		In a cross-sectional study the prevalence of risk factors and of clinically manifest atherosclerosis was ascertained in 3781 adult permanent inhabitants of Slovenia. On the base of gathered data, the relation among the observed factors and the presence of atherosclerosis was meant to be assessed. 17 variables were chosen for the analysis of multivariance: mid upper arm circumference, wrist circumference, systolic pressure, diastolic pressure, body mass index, education, age, diagnosis of hypertension, diagnosis of diabetes mellitus, smoking, place, sex, salt, alcohol, activity, myocardial infarction in family history and total cholesterol. The related variable atherosclerosis is composed from the observed clinial forms of atherosclerosis: angina pectoris, acute myocardial infarction, stroke, atherosclerosis of central nervous system or transient ischemic attack, peripheral arterial occlusive disease. A mathematical probability model for atherosclerosis was built with logistic regression. Records of 3758 persons with 16 determinants (without cholesterol) resp. records with 2899 persons with 17 determinants were included into analysis. A significant positive connection of atherosclerosis with age, diagnosis of hypertension, diabetes mellitus, smoking, sex, and alcohol consumption was ascertained, and a negative connection with physical activity. When only the persons with defined cholesterol were included into analysis, five same variables came into model and the variables diagnosis of diabetes mellitus and sex dropped off. Atherosclerosis was not significantly connected with cholesterol which may be the consequence of methodological weakness of the research.(Abstract truncated at 2000 characters)
Summary		V presečni študiji je bila pri 3781 odraslih stalnih prebivalcih Slovenije ugotovljena razširjenost dejavnikov tveganja in prevalenca klinično očitne ateroskleroze. Na zbranih podatkih smo želeli oceniti povezanost med opazovanimi dejavniki in prisotnostjo ateroskleroze. Za multivariatno analizo smo izbrali 17 spremenljivk: obseg nadlakti, obseg zapestja, sistolični tlak, diastolični tlak, indeks telesne mase, izobrazba, starost, ugotovljena arterijska hiprtenzija, ugotovljeni diabetes miellitus, kajenje, kraj, spol, alkohol, dejavnost, srčni infarkt v družinski anamnezi in celotni holesterol. Odvisna spremenljivka ateroskleroza je sestavljena iz opazovanih kliničnih oblik ateroskleroze: angina pektoris, akutni miokardni infarkt, cerebrovaskularni inzult, ateroskleroza centralnega živčevja ali prehodni napad ishemije, periferna arterijska okluzijska bolezen. Z logistično regresijo smo zdradili matematični model verjetnosti za aterosklerozo. V analizo smo vključili zapise 3758 oseb s 16 determinantami (brez holesterola) oziroma zapise 2899 oseb s 17 determinantami. Dobili smo pomembno pozitivno povezanost ateroskleroze s starostjo, z ugotovljeno arterijsko hipertenzijo, z diabetesom mellitusom, s kajenjem, s spolom in z uživanjem alkohola in negativno povezanost s telesno dejavnostjo. Ko smo vključili v analizo samo osebe z določenim holesterolom, je prišlo v model pet istih spremenljivk, odpadli pa sta spremenljivki ugotovljeni diabetes mellitus in spol. Ateroskleroza ni bila pomembno povezana s holesterolom, kar je lahko posledica metodoloških šibkosti raziskave. Domnevamo, da bi bile opazovane povezanosti močnejše, ko bi imeli zanesljivejše podatke o pretekli izpostavljenosti in ko bi vključili tudi prebivalce, pri katerih je bila posledica ateroskleroze smrt.
Descriptors		ATHEROSCLEROSIS RISK FACTORS CARDIOVASCULAR DISEASES SLOVENIA