Author/Editor		Ravnik-Glavač, Metka; Mašera, Andrej; Ovčak, Zdenka; Glavač, Damjan
Title		Methylation of the von Hippel-Lindau (VHL) tumor suppressor gene in renal cell carcinoma (RCC)
Type		članek
Source		In: Osmak M, Škrk J, editors. Molecular oncology today. Proceedings of the Croatian-Slovenian meeting; 1995 Dec 19; Zagreb. Zagreb: Croatian ligue against cancer,
Publication year		1996
Volume		str. 29-33
Language		eng
Abstract		Changes in the pattern of DNA methylation have been a consistent finding in cancer cells. Fourteen kidney tumors with no somatic mutation in the VHL locus were examined for methylation changes in 5'CpG island of exon 1. In 8 clear cell tumors hypermethylated cytosines were identified while no hypermethylation sites were observed in 6 papillary tumors. These results suggest that methylation of the VHL gene represents another important mechanism of tumor suppressor gene inactivation.
Descriptors		HIPPEL-LINDAU DISEASE CARCINOMA, RENAL CELL GENES, SUPPRESSOR, TUMOR KIDNEY NEOPLASMS DNA METHYLATION POLYMERASE CHAIN REACTION POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL