| Author/Editor | Lavrenčič, Aleša | |
| Title | Vpliv redne telesne vadbe na fibrinolitično aktivnost krvi in endotelijsko vazodilatacijo pri bolnikih z metaboličnim kardiovaskularnim sindromom | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1999 | |
| Volume | str. 55 | |
| Language | slo | |
| Abstract | Background: Favourable effects of physical training on the cardiovascular risk factors have been demonstrated, but there is littte data about the effects of physical training on the cardiovascular risk factors in patients with the metabolic cardiovascular syndrome (MCVS), which includes: insulin resistance, disorders in lipid metabolism, arterial hypertension, and increased thrombogenic potential. There is also no clinical data about the influence of physical training on endothelium-dependent dilation in patients with cardiovascular risk factors, in whom endothelial dysfunction has been demonstrated. The aim of our study was to find out if regular physical activity improves fibrinolysis and endothelium-dependent dilation in patients with MCVS. Subjects and methods: Thirty asymptomatic men with MCVS aged 40 to 60 years were randomly assigned to the controt and the training group, which trained three times a week for 30 minutes during 12 weeks. Before and after the training period, exercise tests and anthropometric measurements were performed and blood glucose, insulin, lipids, apolipoprotein A1, apolipoprotein B, lipoprotein(a), endothelin-1, plasminogen activator inhibitor (PAI) antigen and activity, tissue type plasminogen activator (t-PA) antigen and activity, euglobulin clot lysis time, fibrinogen, and factor VII activity were determined. The insulin resistance was estimated. Using high resolution ultrasound, the diameter of the brachial artery was measured at rest, after reactive hyperemia and after sublingual glyceryltrinitrate. The endothelium-dependent and endothelium-independent dilation was calculated. Results: In comparison with the control group, there was a significant improvement in the maximal exercise capacity (by 18%) and endothelium-dependent dilation (from 5,3+-2,8% to 7,3+-2,7%) in the training group. (abstract truncated at 2000 characters) | |
| Descriptors | ATHEROSCLEROSIS INSULIN RESISTANCE HYPERTENSION THROMBOSIS HYPERLIPIDEMIA ADULT MIDDLE AGE BLOOD GLUCOSE INSULIN EXERCISE TEST EXERCISE BLOOD COAGULATION TESTS BRACHIAL ARTERY VASODILATION HEART RATE BODY WEIGHT CHOLESTEROL TRIGLYCERIDES LIPOPROTEINS, HDL CHOLESTEROL APOLIPOPROTEINS A APOLIPOPROTEINS B ENDOTHELIN-1 |