| Author/Editor | Kašuba, Vilena; Kusić, Zvonko; Garaj-Vrhovac, Vera | |
| Title | Micronuclei in cytokinesis-blocked lymphocytes of patients following iodine-131 radiotherapy | |
| Translated title | Mikro jedra v limfocitih z zavrto citokinezo pri bolnikih po radioterapiji z I-131 | |
| Type | članek | |
| Source | Radiol Oncol | |
| Vol. and No. | Letnik 33, št. 1 | |
| Publication year | 1999 | |
| Volume | str. 35-41 | |
| Language | eng | |
| Abstract | The micronucleus assay in cytochalasin-B cytokinesis blocked peripheral blood lymphocytes in 10 patients with hyperthyreosis and various types of thyroidal carcinomas was investigated. Patients receivcd 259-5180 MBq I-131 sodium iodide perorally. Micronucleus (MN) frequencies were measured before and after I-131 administration. Pre treatment MN results were regarded as controls. Our results show considerable variability concerning age and activity applied. Also, the number of MN and the number of binucleated cells with micronuclei (BNMN) showed Poisson regression adjust for within subject correlation overdispersion. Log dose alone was not significant. The interaction of time and dose was significant at higher doses, while the rate of MN changing was slower. Relative risk time was calculated for the lowest dose (259 MBq). By doubling the dose, the rate of daily increase in the number of MN and BNMN decreases by approximately 5% (Relative risk MN=0.955; Relative riskBNMN= 0.954). | |
| Summary | Pri 10 bolnikih s hipertireozo in različnimi vrstami karcinoma ščitnice smo ra ziskovali mikrci jedra (MN) v limfocitih periferne krvi, v katerih citohalazin-B zavira citokinezo. Bolniki su bili zdravljeni z I-131 natrijevim jodidom, ki so ga dobili peroralno, v odmerkih 259-57K0 MBq. Frekvenco v mikro jedrih smo izmerili pred zdravljenjem z I-131 in po njem. Rezultate merjenja pred zdravljenjem smo uporabili kot kontrolo. Rezultati naše raziskave so bili glecle na starust in trenutno dejavnost precej variabilni. Iz števila mikro jeder in dvojedrnih celic z mikro jedri (BNMN) ter s pomočjo Poissonove regresije, prirerejene autokorelaciji za vsak osebek posebej, je bilo mogoče ugotavljati pretirano disperzijo. Samo pri začetni dozi nismo ugotovili značilne pomembnosti. Pri medsebojnem vplivanju časa in odmerka, še zlasti pri višjih odmerkih, pa smo ugotovili značilno pomebnost, medtem ko so spremembe v jedrih potekale počasneje. Za najnižji odmerek (259 MBq) smo izračunali relativni čas tveganja. Če smo odmerek podvojili, se je število mikro jeder in dvojedrnih celic z mikro jedri zmanjšalo povprečno za 5'%, na dan (relativno tveganje MN = 0.955; relativno tveganje BNMN 0.954). * | |
| Descriptors | HYPERTHYROIDISM THYROID NEOPLASMS IODINE RADIOISOTOPES LYMPHOCYTES MICRONUCLEUS TESTS CYTOCHALASIN B |