Author/Editor		Wagner, Wolfgang; Beeke, Erik; Barsnick, Peter
Title		Radiotherapy for choroidal neovascularisation of age-related macular degeneration
Translated title		Radioterapija neovaskularizirane žilnice pri starostni makularni degeneraciji
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 33, št. 1
Publication year		1999
Volume		str. 55-8
Language		eng
Abstract		Age-related macular degeneration caused by choroidal neovascularisation is an increasing problem in ophthalmology. The results of the therapy in the past were poor or associated with a numher of side, effects. Recently, some reports have shown a beneficial effect of low-dose irradiation. Therefore, we reviewed the data of our patients included in a pilot study to confirm the very preliminary data in literature. Fourtythree patients were irradiated with a linear accelerator (6 MV ) at a total dose of 16 Gy. Six months after irradiation, 69% of our patients maintained or improved their visual acuity. We did not observe side effects or any acute or late sequelae within a median follow-up period of 12 months.
Summary		Starostna makularna degeneracija zaradi neovaskularizacije žilnice predstavlja v oftalmologiji vse večji problem. Zdravljenje doslej ni bilo preveč uspešno in obenem povezano s številnimi stranskimi učinki. Pred kratkim pa smo zasledili ugodne rezultate zdravljenja z obsevanje z nizkimi dozami. Zato smo ponovno proučili podatke o bolnikih, vključenih v pilotsko študijo, da bi lahko potrdili v literaturi objavljene podatke. Raziskava je zajemala 43 bolnikov, ki smo jih obsevali z lineranim akceleratorjem (6 MV) pri skupni dozi l6Gy. Šest mesecev po zaključenem zdravljenju se je pri 69% bolnikov ostrina vida ohranila ali celo izboljšala. Pri proučevanju stran- skih učinkov pa v času spremljanja bolezni v povprečju 12 mesecev nismo zasledili niti akutnih niti kasnih posledic zdravljenja.
Descriptors		MUSCULAR ATROPHY CHOROID NEOVASCULARIZATION, PATHOLOGIC VISUAL ACUITY AGE FACTORS