Author/Editor		Vizjak, Alenka; Ferluga, Dušan; Nagode, Breda; Koselj-Kajtna, Mira; Rozman, Blaž
Title		Significance of antineutrophil cytoplasmic antibodies (ANCA) in the classification of glomerulonephritis
Translated title		Značaj antineutrofilnih citoplazmatskih protutjela (ANCA) u dijagnostici glomerulonefritisa
Type		članek
Source		Acta Med Salin
Vol. and No.		Letnik 27, št. Suppl 1
Publication year		1998
Volume		str. 53-7
Language		eng
Abstract		Antineutrophil cytoptasmic antibodies (ANCA) are a useful marker in the diagnosis of pauci-immune necrotizing crescentic glomerulonephritis with or without systemic vasculitis. These autoantibodies are directed against various cytoplasmic antigens of neutrophil granulocytes and monocytes, the most frequent being proteinase 3 and myeloperoxidase. Two staining pattems are recognized by indirect immunofluorescence: cytoplasmic and perinuclear. ELISA enables the determination antibodies' antigen specificity. Antibodies with specificity for proteinase 3 are highly sensitive for Wegener's granulomatosis and anti-myeloperoxidase antibodies are characteristically found in patients with microscopic polyaniitis and pauci-immune creseentic glomerulonephritis. The term ANCA associated diseases has generally been accepted. However, ANCA can occasionally be positive in various other diseases. mostly in low values. with an atypical immunofluoreseence pattern and specificity for iiiyeloperoxidase or unknown antigen.
Descriptors		GLOMERULONEPHRITIS ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC VASCULITIS WEGENER'S GRANULOMATOSIS ENZYME-LINKED IMMUNOSORBENT ASSAY FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT