Author/Editor		Remškar, Mojca
Title		Prokalcitonin pri bolnikih z akutnim miokardnim infarktom
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1998
Volume		str. 27
Language		slo
Abstract		Increases in C-reactive protein (CRP), ertyhrocyte sedimentation rate (ESR), white blood cell count (WBC) and body temperature are tipically observed in patients with acute myocardial infarction (AMI). Procalcitonin (PCT) is recently described acute phase protein, which increases in the setting of bacterial infection. It has not yet been investigated in patients with AMI. The aim of present study was therefore to relate PCT to CRP, ESR, WBC and body temperature during the early phase of AMI. Maximal PCT values remained below 0.5 micro g/L in patients without severe left heart failure, bacterial infection or cardiac arrest. In patients with pulmonary edema and cardiogenic shock maximal PCT increased up to 5.24 micro g/L. Concomitant cardiac arrest and/or bacterial infection increased PCT up to 134 micro g/L regardless of the severity of left heart failure. This contrasted with CRP, ESR, WBC and body temperature which all increased even in the absence of left heart failure, bacterial infection and cardiac arrest. Maximal CRP increases to 214 mg/L, ESR to 71 mm/h, L to 27.2 x 109/L and body temperature to 38.1 degrees C. Only moderate correlation was observed between PCT and CRP (r = 0.57; p = 0.0001). Poor or statistically nonsignificant correlation was documented between PCT and ESR (r = 0.36; p = 0.008), PCT and WBC (r = 0.14; p = 0.32) and PCT and body temperature (r = 0.29; p = 0.03). In conclusion, determination of PCT may be helpful in differential diagnosis of increased CRP, ESR, WBC and body temperature in patients with AMI. Normal values of PCT in the absence of severe left heart failure of cardiac arrest would argue against severe bacterial infection. (Abstract truncated at 2000 characters).
Descriptors		MYOCARDIAL INFARCTION CALCITONIN C-REACTIVE PROTEIN INTENSIVE CARE UNITS BLOOD SEDIMENTATION LEUKOCYTE COUNT BODY TEMPERATURE ACUTE DISEASE HEART FAILURE, CONGESTIVE PULMONARY EDEMA SHOCK, CARDIOGENIC BACTERIAL INFECTIONS