Author/Editor		Tomšič-Matić, Marjeta
Title		Citokini v diagnostiki hude okužbe pri novorojenčku
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1998
Volume		str. 76
Language		slo
Abstract		Objective: To asses the value of determination of IL-6 and soluble IL-2 receptors (sIL-2R) in the diagnosis of severe infection in the critically ill newborns; to determine whether they are faster and more sensitive markers of infection that CRP, white cell count and differential; to determine whether sequential determination improves diagnostic value; to determine whether serum concentrations of IL-6 and sIL-2R are lower in sepsis due to coagulase negative staphylococci than other bacteria; to determine the correlation between IL-6 and CRP. Patients and methods: Prospective study from December 1995 to December 1997 included 46 critically ill newborns admitted to neonatal intensive care unit who had clinical and/or laboratory signs of sepsis. Patients were divided into three groups: group 1 - clinically septic newborns with positive cultures, group 2 - clinically septic newborns with negative cultures and group 3 (control group) - newborns with respiratory distress without laboratory signs of infection. The sera were collected three times at 12-h intervals. The levels of IL-6 and sIL-2R were compared with routinely used markers of infection CRP and WBC count and differential. IL-6 and sIL-2R were measured by enzyme-linked immunosorbent assay (ELISA) method. We used commercial kit Endogen Inc., Cambridge, MA, USA. Results: Fourteen newborns had microbiologically confirmed severe infection (sepsis, pneumonia, meningitis) (group 1), twelve newborns had only clinical and laboratory signs od sepsis (group 2) and twenty newborns had respiratory distress syndrome (group 3). (Abstract truncated at 2000 characters).
Descriptors		SEPSIS INTERLEUKIN-6 RECEPTORS, INTERLEUKIN-2 INTENSIVE CARE UNITS, PEDIATRIC INFANT, NEWBORN RESPIRATORY DISTRESS SYNDROME LEUKOCYTE COUNT PLATELET COUNT