Author/Editor     Janež, Andrej
Title     Vpliv oligoelementa kroma na krvni tlak
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     1998
Volume     str. 38
Language     slo
Abstract     The oligoelement chromium in the human organism, its metabolism and influences upon diverse functions are research topics which have been frequently treated by leading researchers worldwide during the last two decades. Many facts have been proved by experiments on animals, while those related to the function of chromium in man, have remained unexplained. Our invastigation dealt with one such area. It was aimed at determining the influence of chromium on human blood pressure, which has already been confirmed in rats. The quantity of chromium in hair and urine was measured in a test group of 50 randomly chosen male and female workers in leather industry, since their working environment is over-exposed tochromium in the form of aerosols as well as in direct contact with chromium comounds. Chromium concentrations were determined by atomic absorption spectromy, and the content of insulin in blood serum according to the RIA-Sorin Biomedica laboratory method. Standardized measurements of sistolic and diastolic blood pressure and insulin in serum were carried out in all group members. The control group consisted of 43 people who had normal blood pressure and have not been treated for any kind of cardiovascular condition. The same procedures were used in both groups, which were equalized with regard to structure and age. A statistical analysis of data shows significant differences: - The concentration of chromium in hair of the test group is statistically higher than the concentration in urine (p<0,01). - The concentrations of chromium in hair and urine are significantly higher in the test group than in the control group (p<0,01). - The increased concentrations of chromium in hair and urine, which relfect the increased chromium content in the organism, result in a sigificant decrease in the sistolic blood pressure in members of the test group (p<0,01).(Abstract truncated at 2000 characters)
Descriptors     CHROMIUM
HAIR
OCCUPATIONAL EXPOSURE
BLOOD PRESSURE
INSULIN
ADULT
RADIOIMMUNOASSAY
SPECTROPHOTOMETRY, ATOMIC ABSORPTION
SYSTOLE
DIASTOLE
AIR POLLUTANTS