Author/Editor		Oblak, Duša; Brumen, Marjeta
Title		Mesto in pomen kalcijevih antagonistov pri zdravljenju hipertenzije
Translated title		Calcium antagonists - their place and importance in the treatment of hypertension
Type		članek
Source		Krka Med Farm
Vol. and No.		Letnik 18, št. 29
Publication year		1997
Volume		str. 24-33
Language		slo
Abstract		Calcium antagonists are an important group of drugs for the reatment of cardiovascular diseases. They inhibit normal transmembrane influx of calcium through the L-type calcium channels, dependent on which are the contraction of the smooth muscle cells, myocardial cells, and the formation of impulses. In this way calcium antagonists cause systemic and coronary vasodilation, reduce the contractility of the myocardium and the formation of impulses. Consequently they may be used for the treatment of hypertension, ischemic heart disease and certain types of arrhythmia. Hypertension is the disease in which calcium antagonists are most widely and frequently used. The present article deals with the polemics concerning use of calcium antagonists.
Summary		Kalcijevi antagonisti so pomembna skupina zdravil za zdravljenje kardiovaskularnih obolenj. Zavirajo normalen transmembranski prehod kalcijevih ionov skozi L-tip kalcijevih kanalov, od česar je odvisno krčenje gladkih mišIčnih in srčnih celic ter nastajanje impulzov. Kalcijevi antagonisti na ta način povročajo sistemsko in koronarno vazodilatacijo ter zmanjšujejo krčljivost srca in nastajanje impulzov. Zato jih lahko uporabljamo za zdravljenje hipertenzije, ishemične srčne bolezni in nekaterih aritmij. Hipertenzija je obolenje, ki ga najpogosteje zdravimo, s kalcijevimi antagonisti. V članku so obravnavane polemike o uporabi kalcijevih antagonistov.
Descriptors		CALCIUM CHANNEL BLOCKERS NIFEDIPINE DILTIAZEM VERAPAMIL CARDIOVASCULAR DISEASES HYPERTENSION CLINICAL MEDICINE PHARMACOKINETICS MORTALITY