Author/Editor		Beović, Bojana
Title		Součinkovanja protimikrobnih zdravil
Translated title		Interactions of antimicrobials
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 38, št. Suppl 2
Publication year		1999
Volume		str. 77-95
Language		slo
Abstract		Clinically significant interactions between antimicrobial agents are not very common, but attention should be paid in the case of patients taking multiple drugs, the severely ill and patients with impaired kidney or liver function. There are two principal kinds of interaction: pharmacokinetic and pharmacodynamic. Some interactions may take place even before the entrance of the drugs into the body, but most drugs interact at the site of absorption, distribution, and excretion. The most frequently described interadions between antimicrobials are with macrolides, azole antifurgals, rifampicin, quinolones, tetracyclines and some antiretroviral agents. Some therapeuticaly useful antimicrobial interactiorms are the basis of rational polypharmacy.
Summary		Čeprav klinično pomembna součinkovanja protimikrobnih zdravil niso pogosta, je na njih treba pomisliti predvsem pri bolnikih, ki prejemajo več zdravil hkrati ali so hudo bolni ali imajo moteno delovanje ledvic ali jeter. Součinkovanje delimo na farmakokinetično in farmakodinamsko. Medsebojni vpliv zdravil je možen pred vstopom zdravila v telo, na ravni absorpcije, porazdelitve, presnove in izločanja. Najpogostejša so farmakokinetična součinkovanja zdravil z makrolidnimi antibiotiki, azolnimi antimikotiki, rifampicinom, kinoloni, tetraciklini in z nekaterimi protiretrovirusnimi zdravili. Farmakodinamsko součinkovanjeje pomembno za uporabo protimikrobnih zdravil v kombinacijah.
Descriptors		ANTIBIOTICS DRUG INTERACTIONS HIV INFECTIONS