| Author/Editor | Videčnik, Viktor; Kozak, Matija; Blinc, Aleš | |
| Title | Terapevtska angiogeneza | |
| Translated title | Therapeutic angiogenesis | |
| Type | članek | |
| Source | Med Razgl | |
| Vol. and No. | Letnik 38, št. Suppl 3 | |
| Publication year | 1999 | |
| Volume | str. 136-40 | |
| Language | slo | |
| Abstract | In the past decade it has been proven in animal models of limb ischemia and myocardial ischemia that angiogenic factors used in therapeutic doses induce the development of small collatetal vessels that protect tissue from ischemia injury. The majority of studies have been conducted with either basic fibroblast growth factor or vascular endothelial growth factor (VEGF). A similar therapeutic effect as with direct aplication of the peptide VEGF into ischemic tissue was achieved with gene transfer of naked plasmid DNA encoding for VEGF. In recent years, sucessful clinical use of therapeutic angiohenesis has been reported on a limited number of patients with critical limb ischemia or advanced coronary artery disease. In order to further characterize the safety and efficancy of therapeutic angiogenesis in human patients, larger randomized studies are needed. | |
| Summary | V zadnjem desetletju so raziskovalci na živalskih modelih ishemije uda in ishemije srčne mišice dokazali, da je z uporabo terapevtskih odmerkov angiogenih rastnih dejavnikov mogoče vzpodbuditi razvoj drobnega kolateralnega žilja in zmanjšati škodljive učinke ishemije v tkivih. Večina študij je uporabljala bazični fibroblastni rastni dejavnik ali žilni endotelni rastni dejavnik (VEGF). Podoben zdravilni učinek kot z neposrednim vnašanjem peptida VEGF so dosegli, ko so v ishemično tkivo vnesli genski zapis za VEGF v obliki gole plazmidne DNA. V zadnjih letih so se pojavila prva klinična poročila uspešni uporabi terapevtske aangiogeneze pri reševanju ishemičnih udov in zdravljenju napredovale koronarne srčne bolezni. Za natančnejšo opredelitev varnosti in uspešnosti metode pri bolnikih bodo potrebne večje randomizirane študije. | |
| Descriptors | ARTERIAL OCCLUSIVE DISEASES MYOCARDIAL ISCHEMIA ANGIOGENESIS FACTOR COLLATERAL CIRCULATION FIBROBLAST GROWTH FACTOR, BASIC |