Author/Editor		Jekovec-Vrhovšek, Maja
Title		Vpliv kalcija in vitamina D na kostno gostoto z vidika kvalitete življenja otrok in mladostnikov z najtežjo motnjo v razvoju
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1998
Volume		str. 47
Language		slo
Abstract		In severely physically-handicapped children and adolescents with cerebral palsy and epilepsy, atraumatic fractures of the long bones are often seen. The reason for the increased bone fragility was postulated to be osteopenia due to immobilisation and antiepileptic treatment. Twenty children, who were suffering from the most severe form of cerebral palsy and had been treated with antiepileptic drugs for a relatively long period of time, were included in the study. Physical examination and laboratory analyses excluded other possible causes of osteopenia. The bone turnover was assessed by biochemical and hormonal analyses. Bone mineral density was measured by dual x-ray absorptiometry. The initial bone density was very low (from 0.156 to 0.715 g/cm2). The 25-hydroxy vitamin D plasma concentrations ranged from 1 - 64 nmoUL (reference range 40-185 nmoUL). 13 patients (four of whom had already suffered from one to three long bone fractures) were treated for 9 months with 1,25-dihydroxy-cholecalciferol vitamin D (0.25 mcg daily) and with calcium (500 mg daily). After nine months bone mineral density values were found to be significantly higher (p< 0.001 ). In the interval between the first and the second measurement seven patients were not given any vitamin D or calcium. At the time of the control measurement their bone mineral density values were significantly lower (p<0.01). It can be concluded that the addition of vitamin D and calcium cures osteopenia in children with the most severe form of cerebral palsy, who are receiving antiepileptic drugs.
Descriptors		CALCIUM BONE DENSITY VITAMIN D DEVELOPMENTAL DISABILITIES CHILD ADOLESCENCE CEREBRAL PALSY EPILEPSY FRACTURES, SPONTANEOUS