Author/Editor		Marčun-Varda, Nataša
Title		Polimorfizem gena za angiotenzinsko konvertazo (ACE I/D) kot srčnožilni dejavnik tveganja pri otrocih
Translated title		Angiotensin-converting enzyme gene polymorphism (ACE I/D) as cardiovascular risk factor in children
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1999
Volume		str. 51
Language		slo
Abstract		A family history of cardiovascular disease predicts cardiovascular risk in the next generation, which is either the result of inherited traits or certain living habits in some families. In recent years intensive research was done in the field of genetic factors. The aim of our study was to evaluate both sides and particularly the role of one of possible genetic risk factors - angiotensin-converting enzyme (ACE) gene polymorphism in children of parents with cerebral stroke before the age of 45. We were especially interested in the association of this polymorphism with carotid wall thickness - intima media thickness (IMT) which is regarded as the earliest morphological evidence of atherosclerotic disease. We also attempted to test the association between ACE I/D polymorphism and some anamnestic, anthropometric and biochemical parameters in children of parents with premature cerebral stroke. We also evaluated the differences between the case and the control group (without a positive family history) and the need for some preventive measures in the case group. Two groups of children were studied : children whose parents had cerebral stroke before the age of 45 (our case group) and children without positive family history (our control group). In each individual, the family history as well as the history of living habits was taken. Anthropometrical measurements were taken and casual blood pressure was measured. Serum cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, glucose, fibrinogen, insulin and uric acid were determined. Microalbuminuria was looked for as well. ACE gene polymorphism was performed using the PCR method. IMT was measured by real-time ultrasound. Investigating the differences between the two groups, no statistically significant differences were found in the values of biochemical parameters. No significant differences between the two groups were determined either in IMT or ACE I/D polymorphism. (Abstract truncated at 2000 characters)
Descriptors		CARDIOVASCULAR DISEASES PEPTIDYL-DIPEPTIDASE A CAROTID ARTERIES ATHEROSCLEROSIS CHILD POLYMORPHISM (GENETICS) TUNICA INTIMA TUNICA MEDIA BLOOD PRESSURE RISK FACTORS ANTHROPOMETRY BODY MASS INDEX CHOLESTEROL TRIGLYCERIDES BLOOD GLUCOSE FIBRINOGEN URIC ACID INSULIN CHILD