Author/Editor		Cimerman, M; Gunde-Cimerman, N; Zalar, P; Perković, T
Title		Femur osteomyelitis due to a mixed fungal infection in a previously healthy man
Type		članek
Source		J Clin Microbiol
Vol. and No.		Letnik 37, št. 5
Publication year		1999
Volume		str. 1532-5
Language		eng
Abstract		We describe a previously healthy, 22-year-old man who, after a closed fracture of the femur and subsequent operation, developed chronic osteomyelitis. Within a few days, infected bone fragments, bone, and wound drainage repeatedly yielded three different filamentous fungi: Aspergillus fumigatus, Aspergillus flavus, and Chalara ellisii. Histologic examination of the bone revealed septate hyphae. After sequential necrotomies of the femur and irrigation-suction drainage with added antimycotic therapy, the infection ceased and the fracture heald. This case is unique in that it is the only known instance in which a long bone was affected in an immunocompetent individual, with no evidence of any systemic infection, by a mixed population of two different Aspergillus spp. and the rare filamentous fungus C. ellisii. Environmental factors that could potentiate the infection include blood and edema fluid resulting from the surgical procedure and the presence of the osteosynthetic plate.
Descriptors		ASPERGILLOSIS FEMORAL FRACTURES OSTEOMYELITIS POSTOPERATIVE COMPLICATIONS ADULT ASPERGILLUS