Author/Editor		But, Igor
Title		Molekularna biologija karcinoma jajčnika
Translated title		Molecular biology of ovarian carcinoma
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 68, št. 4
Publication year		1999
Volume		str. 251-4
Language		slo
Abstract		Background. In this review, some new findings regarding the development and progress of the epithelial ovarian cancer are presented. In the mechanism of malignant transformation, the minimal gentic changes of specific chromosomes are involved, this may lead to the altered expression of certain oncogenes and tumor-suppressor genes. During the progress of the disease the number of genetic alterations increases, what results in a higher agressiveness of the tumor. Conclusions. In this article the clinical consequences of the altered expression of certain oncogenes and tumor-suppressor genes are presented, as well as their influence on the prognosis of the patients with ovarian carcinoma.
Summary		Izhodišča. V preglednem članku so prikazana nekatera nova spoznanja o nastanku in napredovanju karcinoma jajčnika. V mehanizem maligne preobrazbe so vpletene minimalne genetske spremembe specifičnih kromosomov, kar vodi v spremenjeno aktivnost določenih onkogenov in tumorskih supresorskih genov. Pri napredovanju bolezni Število genskih modifikacij in genetskih napak narašča, s čimer narašča tudi agresivnost tumorja. Zaključki. V delu je predstavljen klinični pomen spremenjene aktivnosti posameznih onkogenov in tumorskih supresorskih genov ter njihov vpliv na prognozo bolnic s karcinomom jajčnika.
Descriptors		OVARIAN NEOPLASMS ONCOGENES EPIDERMAL GROWTH FACTOR-UROGASTRONE RECEPTORS, EPIDERMAL GROWTH FACTOR-UROGASTRONE TRANSFORMING GROWTH FACTOR ALPHA TRANSFORMING GROWTH FACTOR BETA PROTO-ONCOGENES