Author/Editor     Žižek, Bogomir
Title     Vloga žilnih in biokemičnih sprememb v krvi pri esencialni arterijski hipertenziji
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     1999
Volume     str. 76
Language     slo
Abstract     Essential arterial hypertension (EAH) is an important risk factor for atherosclerosis. Etiology and pathogenesis of EAH is not known yet. Abnormalities found in patients could be related to the underlying cause of EAH or may be only the consequences of long-standing elevated blood pressure. We studied functional and morphological arterial wall abnormalities in hypertonics without evidence of cardiovascular events. The study was focused on biochemical changes, which are thought to be a part of the polymetabolic syndrome and which could have some influence on hemorheology and atherogenesis. In our study we wanted to find arterial wall and blood structure changes that are characteristic for the group of individuals with hypertnesive familial trait. Thickness of the intima and media (IMT) of the carotid arteries and changes in the blood flow and the diameter of the brachial artery (flow-dependent) dilation (FMD) were measured. IMT was measured by B-mode ultrasound, while dilation of peripheral artery was evaluated by the provocation test occuring during reactive hyperaemia and after administration of glyceriltrinitrate. 46 hypertonics (mean age 49 years) without evidence of major cardiovascular events, were divided into two subgroups. In the first grou there were 22 hypertonics treated with Ca-channel blockers and in the second group 24 patients treated with angiotensin converting enzyme inhibitors. 44 healthy normotensive and age-matched subjects served as controls. We also tested 41 offspring (familial trait-FT) of subjects with EH (mean age 25 years) and 41 age- and sex-matched controls without FT. (Abstract truncated at 2000 characters.)
Descriptors     HYPERTENSION
CAROTID ARTERIES
BRACHIAL ARTERY
BLOOD FLOW VELOCITY
MIDDLE AGE
TUNICA INTIMA
TUNICA MEDIA
VASODILATION
NITROGLYCERIN
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
BODY MASS INDEX
ANTHROPOMETRY
ATHEROSCLEROSIS
LEUKOCYTE COUNT
TRANSFERRIN
ANTHROPOMETRY
FIBRINOGEN
BLOOD VISCOSITY
BLOOD PROTEINS
TRIGLYCERIDES
INSULIN