| Author/Editor | Pirtošek, Zvezdan; Merello, Marcelo; Carlsson, Arvid; Stern, Gerald | |
| Title | Preclamol and parkinsonian fluctuations | |
| Type | članek | |
| Source | Clin Neuropharmacol | |
| Vol. and No. | Letnik 16, št. 6 | |
| Publication year | 1993 | |
| Volume | str. 550-4 | |
| Language | eng | |
| Abstract | Preclamol, the (-)enantiomer of 3-PPP (=3(3-hydroxyphenyl)-N- n-propyl piperidine), has a selective dopamine autoreceptor- and postsynaptic mixed agonist-antagonist profile. Its action on patients with disabling on-off parkinsonian fluctuations has been studied and compared with those of placebo and subcutaneous apomorphine. Preclamol had a mild but unequivocal antiakinetic effect, less than that caused by subcutaneous apomorphine, but it provoked less dyskinesia. Further studies to explore the therapeutic potential of preclamol seem justified. | |
| Descriptors | PARKINSON DISEASE ANTIPARKINSON AGENTS PIPERIDINES APOMORPHINE BLOOD PRESSURE DOPAMINE AGONISTS INJECTIONS, SUBCUTANEOUS MOVEMENT RECEPTORS, DOPAMINE D1 RECEPTORS, DOPAMINE D2 |