Author/Editor		Reberšek-Gorišek, Jelka; Baklan, Zvonko; Kotnik-Kevorkijan, Božena
Title		Klinični potek okužbe z virusom Epstein-Barr
Type		članek
Source		In: Reberšek-Gorišek J, Baklan Z, Kotnik-Kevorkijan B, editors. Okužbe s humanimi herpesvirusi. Zbornik predavanj in praktikum Bedjaničev simpozij z mednarodno udeležbo; 1999 jun 11-12; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		1999
Volume		str. 73-89
Language		slo
Abstract		Epstein-Barr virus (EBV) infections are frequent. Close contact is required for the transmission of infection which may have an asymptomatic course, but is most often manifested as a clinical syndrome of infectious mononucleosis with increased body temperature, pharyngitis and lymph node hypertrophy. Of the laboratory findings, the hemogram most often reveals lymphocytosis with presence of atypical lymphocytes while biochemical findings show increased liver transaminase levels. In the elderly, the clinical picture sometimes differs from the classical and the disease often runs a severe course. As a rule, the clinical picture regresses and there is spontaneous recovery. However, serious complications may occur, leading to death. Such a course of disease is most often associated with immunosuppression, but it may also be found in previously healthy people. EBV is also associated with numerous carcinomas, but the mechanism of action and oncogenesis has not been elucidated. Recovery after primary infection is spontaneous in most cases. In a more severe course and in case of complications, however, no effective, antivirus drug is at ourdisposal. At the Department of Infectious Diseases of Maribor Teaching Hospital, EBV infected patients are treated as outpatients. Onlythosewith a serious clinical picture and unclear diagnosis are hospitalized. In patients treated at our Department between 1994 and 1998, signs typical of infectious mononucleosis (IM) were established. There was a female patient with severe course and complications as defined by cholestaticjaundice. All patients recovered spontaneously.
Descriptors		HERPESVIRUS 4, HUMAN INFECTIOUS MONONUCLEOSIS HERPESVIRIDAE INFECTIONS