Author/Editor		Bračič, K; Žic, L; Todorovič-Guid, M; Kanič, Z; Roškar, Z
Title		Možnosti ugotavljanja delovanja plodove ledvice danes in jutri
Translated title		The possibilities assesing fetal renal function today and in the future
Type		članek
Source		Slov Pediatr
Vol. and No.		Letnik 5, št. Suppl 1
Publication year		1998
Volume		str. 181-4
Language		slo
Abstract		The use of ultrasonography during pregnancy has led to the identification of a large number of renal and urinary tract abnormalities, particularly hydronephrosis. Uncertainty exists regarding the indications for surgical intervention. The variables, currently used to assess fetal renal function and predict the long-term outcome, are measurements of urinary concentration of electrolytes and low molecular weight proteins. The analysis of these variables reveals that single measurements of any of these variables is unlikely to be reliable. Sequential measurements are impractical due to the narrow window of opportunity for useful surgical intervention. It is necessary to search for innovative approaches aimed at detecting changes in the kidney or urine that reflect the biological response of the developing kidney to injury. Such markers may be represented by renal metabolites or peptides involved in the maintenance of renal function under conditions of stress.
Descriptors		PRENATAL DIAGNOSIS KIDNEY KIDNEY FUNCTION TESTS PREGNANCY HYDRONEPHROSIS