| Author/Editor | Kores-Plesničar, Blanka; Velikonja, Ingrid | |
| Title | Genetika shizofrenije | |
| Translated title | Genetics of schizophrenia | |
| Type | članek | |
| Source | Med Razgl | |
| Vol. and No. | Letnik 38, št. 1 | |
| Publication year | 1999 | |
| Volume | str. 117-29 | |
| Language | slo | |
| Abstract | The authors give a brief description of schizophrenia based on the established international criteria, and discuss its epidemiology and aetiology. They present family, twin and adoption studies wich have reinforced the role of genetic factors in the aetiology of schizophrenia. Next they discuss various inheritance patterns, the hypothesis of the site of a single gene locus for schizophrenia and role of non-genetics factors. Recent studies aimed at detecting and localizing the dominant gene linked to schizophrenia on a locus of chromosome 6 seem most promising, yet evi- dence is accumulating that the mode of inheritance is either polygenic (caused by many genes exerting slight effects), or oligogenic (caused by a few genes exerting moderate effects), with an important role being played by environmental factors. Modern genetic methods will certainly improve our understanding of the aetiology and development of schizophrenia in the foreseeable future. | |
| Summary | Avtorici najprej kratko predstavita shizofrenske motnje po veljavnih mednarodnih klasifikacijskih merilih, njihovo epidemiologijo in izvor. Opisane so raziskave rodovnikov velikih družin, dvojčkov in posvojencev, ki potrjujejo pomembno vlogo genetskega dejavnika pri razvoju shizofrenije. Omenjeni so različni načini njenega genetskega prenosa, hipoteze o lokalizaciji lokusa za shizofrenijo kot tudi pomen in vloga negenetskih dejavnikov. Pri odkrivanju dominantnega gena za shizofrenijo v zadnjem času največ obetajo proučevanja sumljivih lokusov na kromosomu 6, čeprav se vse bolj uveljavlja prepričanje o poligenskem (nekaj genov z zmernim vplivom) oziroma oligogenskem (več genov z manjšim vplivom) načinu dedovanja, seveda ob upoštevanju raznovrstnih dejavnikov okolja. Sodobne genetske metode bodo v prihodnosti nedvomno omogočile boljše poznavanje in razumevanje na- stanka, prenosa in razvoja shizofrenije. | |
| Descriptors | SCHIZOPHRENIA PEDIGREE CHROMOSOME ABNORMALITIES CHROMOSOMES, HUMAN, PAIR 5 CHROMOSOMES, HUMAN, PAIR 11 CHROMOSOMES, HUMAN, PAIR 22 X CHROMOSOME |