Author/Editor		Ekart, Robert; Dvoršak, Benjamin; Hojs, Radovan; Gorenjak, Maksimiljan
Title		Lipoprotein(a) pri bolnikih s končno odpovedjo ledvic, zdravljenih s kronično hemodializo
Translated title		Lipoprotein(a) in patients with end-stage renal failure treated with maintenance hemodialysis
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 68, št. 7-8
Publication year		1999
Volume		str. 429-32
Language		slo
Abstract		Background. Disturbances of lipid metabolism are frequent in patients with chronic renal failure, treated with maintenance hemodialysis. Increase of serum lipoprotein(a), known risk factor for cardiovascular diseases common in dialysis patients was also reported. Methods. Thirty-six dialysis patients were included in our study. Serum concentration of lipoprotein(a), total cholesterol, LDL and HDL cholesterol, triglycerides, apolipoprotein A I, apoli- poprotein B, albumin and parathormone were determined. Serum concentration of lipoprotein(a) was compared wlth that in 36 healthy blood donors who were matched for age and sex with dialysis patients. Results. Serum concentration of lipoprotein(a) was significantly higher in dialysis patients than in healthy blood donors. We didn't find correlation between lipoprotein(a) and age, dialysis treatment time, serum concentration of total cholesterol, LDL and HDL cholesterol, triglycerides, apolipoprotein A-I, apolipoprotein B, albumin and parathormone in dialysis patients. Conclusions. Serum concentration of lipoprotein(a) is increased in patients with end stage renalfailure, treated with maintenance hemodialysis. Unfortunately, effective treatmont to lowerserum concentration of lipoprotein(a) is not known. So very strict management of other atherosclerotic risk factors in dialysis patients is recommended.
Summary		Izhodišča. Bolniki s kronično odpovedjo ledvic, zdravljeni s hemodializo, imajo pogosto moteno presnovo lipidov. Opisali so tudi zvišano serumsko koncentracijo lipoproteina(a), ki je znan kot nevarnostni dejavnik za kardiovaskularne bolezni, ki so pri dializnih bolnikih pogoste. Metode. V raziskavo smo vključili 36 dializnih bolnikov, ki smo kim izmerili serumsko koncentracijo lipoproteina(a), celotnega holesterola, trigliceridov, apolipoproteina A-I, apolipoproteina B, albumina in parathormona. Kontrolno skupino je sestavljalo 36 zdravih krvodajalcev, ki so bili po starosti in spolu usklajeni z dializnimi bolniki. Pri njih smo določili le serumsko koncentracijo lipoproteina(a). Rezultati. Serumska koncentracija lipoproteina(a) je bila pri dializnih bolnikih statistično značilno višja kot pri skupini zdravih krvodajalcev. Nismo našli povezave med lipoproteinom(a) in starostjo bolnikov, časom dializnega zdravljenja, serumsko koncentracijo celotnega holesterola, trigliceridov, HDL in LDL holesterola, apolipoproteinom A-I, apolipoproteinom B, albumini ter parathormonom. Zaključki. Pri bolnikih s kronično odpovedjo ledvic, zdravljenih s hemodializo, je koncentracija lipoproteina(a) v serumu zvišana. Žal učinkovoto zdravljenje zaenkrat ni znano. Zato je pomembno, da čimbolj zmanjšamo učinek preostalih nevarnostnih dejavnikov za razvoj ateroskleroze pri dializnih bolnikih.
Descriptors		KIDNEY FAILURE, CHRONIC HEMODIALYSIS LIPOPROTEIN(A) HYPERLIPIDEMIA ATHEROSCLEROSIS RISK FACTORS