| Author/Editor | Vidan-Jeras, B; Breur-Vriesendorp, B; Bohinjec, M; Jeannet, M; Roosnek, E; Tiercy, J-M | |
| Title | HLA-B44 allele frequencies and haplotypic associations in three European populations | |
| Type | članek | |
| Source | Eur J Immunogenet | |
| Vol. and No. | Letnik 24 | |
| Publication year | 1997 | |
| Volume | str. 335-43 | |
| Language | eng | |
| Abstract | HLA-B44 is among the most frequent class I antigens in many populations studied so far. It has been subdivided into seven allelic forms that can only be discriminated by DNA typing. Using a simple PCR/sequence-specific oligonucleotide hybridization procedure, we have analysed the frequency distribution of B44 subtypes in three European populations from Slovenia, the Netherlands, and Switzerland. B*4402 and B*4403 were by far the predominant alleles, B*4404 and 4405 were rare, while B*4406 and B*4407 were not observed. Interestingly, B*4402 and 4403 occurred with different frequencies in the three populations, with B*4402 being most frequent in the Swiss (65% vs. 57% in the Dutch, and 46.5% in the Slovenes). Of the 139 individuals studied, 60 HLA-B44 ABDR haplo- types could be determined by family studies. In the respective populations, the linkage disequilibria between B44 and other HLA antigens occurred with different frequencies. A2-B*4402 haplotypes were very frequent in the Swiss sample, mostly associated with DRB 1 *0101, 0401 and 1301. B*4402 was more often linked with non-A2 antigens in the Slovenes (predominantly A24, A28) than in the Swiss and the Dutch. The predominant association of B*4403 was with DR7: this haplotype was very frequent in the Swiss (82% of the B*4403 haplotypes), while lower frequencies were found in the Dutch (72%) and Slovenian (59%) populations. In the Swiss population, more than half of the B44-DR7 haplotypes were A23-B*4403-DR7 (53% of all B*4403 haplotypes). This haplotype was significantly less frequent in the Slovenian (6%) and in the Dutch (14%) populations. (Abstract truncated at 2000 characters.) | |
| Descriptors | HLA-B ANTIGENS HAPLOTYPES ALLELES BLOOD DONORS CAUCASOID RACE GENE FREQUENCY HLA-A ANTIGENS HLA-DR ANTIGENS LINKAGE DISEQUILIBRIUM NETHERLANDS SLOVENIA SWITZERLAND TISSUE DONORS |