Author/Editor		Sinkovič, Andreja
Title		Pretreatment plasminogen activator inhibitor-1 (PAI-1) levels and the outcome of thrombolysis with streptokinase in patients with acute myocardial infarction
Type		članek
Source		Am Heart J
Vol. and No.		Letnik 136, št. 3
Publication year		1998
Volume		str. 406-11
Language		eng
Abstract		The risk for reinfarctions ond delays in reperfusion after streptokinase therapy may be caused by the antifibrinolytic effect of platelet-derived type 1 plasminogen activator inhibitor (PAI-1 ). This study aims to show the relation of pretreatment PAI-1 levels of patients with acute myocardial infarction treated with streptokinase therapy and the outcome of fibrinolysis, with the emphasis on reperfusion and reinfarction. Methods. Pretreatment PAI-1 levels of 60 patients with acute myocardia) infarction, treated with streptokinase, were determined by the chromogenic method. Failure of thrombolysis with streptokinase was present when reperfusion was delayed as assessed by noninvasive reperfusion criteria, or reinfarctions developed. Results. Mean pretreatment PAI-1 level of patients was 6.3+-1.2 U/ml; span 1.2 U/ml to 34.0 U/ml. Thrombolysis with streptokinse failed significantly in patients with pretreatmenf PAI-1 levels >4.0 U/ml (p < 0.05), mainly becouse of significant occurrence of reinfarction (p < 0.05), but less to delayed reperfusion (p > 0.05). Conclusion. Failure of thrombolysis with streptokinase is significantly associated with pretreatment PAI-1 levels of >4.0 U/mI.
Descriptors		FIBRINOLYTIC AGENTS MYOCARDIAL INFARCTION PLASMINOGEN ACTIVATOR INHIBITOR 1 STREPTOKINASE THROMBOLYTIC THERAPY AGED MIDDLE AGE TREATMENT OUTCOME