| Author/Editor | Mesec, A; Šega, S; Trošt, M; Pogačnik, T | |
| Title | The deterioration of cardiovascular reflexes in Parkinson's disease | |
| Type | članek | |
| Source | Acta Neurol Scand | |
| Vol. and No. | Letnik 100 | |
| Publication year | 1999 | |
| Volume | str. 296-9 | |
| Language | eng | |
| Abstract | Objectives - We have investigated the determination of cardiovascular reflexes in Parkinson's disease. Patients and methods - In a group of 20 patients with Parkinson's disease (PD) and in a group of 10 age-matched control subjects a battery of cardiovascular reflex (CVR) tests (Valsalva manoeuvre, deep breathing test, handgrip test, orthostatic test) was repeated after 3 years. Results - In PD patients at deep breathing test, at Valsalva manoeuvre nad at orthostatic test the heart rate response decreased significantly (P<0.05). The impairment of systolic and diastolic blood pressure response at orthostatic test was significant as well (P<0.005). At hand grip test no significant changes in heart rate and blood pressure response were found. In control subjects only heart rate response at orthostatic test decreased significantly after 3 years. Conclusion - Our results show progression of an impairment of sympathetic and parasympathetic control of the cardiovascular functions in patients with PD over a period of 3 years. | |
| Descriptors | PARKINSON DISEASE CARDIOVASCULAR SYSTEM HEART FUNCTION TESTS AUTONOMIC NERVOUS SYSTEM VALSALVA'S MANEUVER BREATH TESTS HEART RATE BLOOD PRESSURE |