| Author/Editor | Serša, Gregor; Štabuc, Borut; Čufer, Tanja; Jančar, Boris; Miklavčič, Damijan; Čemažar, Maja; Rudolf, Zvonimir | |
| Title | Elektrokemoterapija malignega melanoma | |
| Translated title | Electrochemotherapy of malignant melanoma | |
| Type | članek | |
| Source | Radiol Oncol | |
| Vol. and No. | Letnik 33, št. Suppl 1 | |
| Publication year | 1999 | |
| Volume | str. S55-63 | |
| Language | slo | |
| Abstract | Electrochemotherapy is a novel cancer treatment approach, that combines application of electric pulses to a tumor with standard chemotherapeutic drugs. Electric pulses induce transient and reversible cell membrane destabilization that results in facilitated drug delivery into the cell, and consequently their better antitumor effectiveness. Electrochemotherapy has proved to be effective with two cytostatic agents, bleomycin and cisplatin. Good clinical results have been reported in the treatment of cutaneous and subcutaneous tumor nodules of squamous head and neck carcinoma, malignant melanoma, squamous cell carcinoma, adenocarcinoma and Kaposi's sarcoma. The percentage of complete responses to the electrochemotherapy treatment is above 80 %. Therefore, electrochemotherapy is a promising new approach in the treatment of cutaneous and subcutaneous tumor nodules of malignant melanoma that utilizes the application of electric pulses to the tumor as a drug delivery system. | |
| Summary | Elektrokemoterapija je način zdravljenja raka, ki združuje uporabo standardnih kemoterapevtikov in aplikacijo električnih impulzov na področju tumorja. Električni pulzi povzroče elektroporacijo, to je prehodno destabilizacijo celičnih membran, kar omogoči lažji prehod citostatikov v citosol in s tem njihovo večjo učinkovitost. Elektrokemoterapija se je pokazala učinkovita z dvema citostatikoma, bleomicinom in cisplatinom. Dobri klinični rezultati so znani pri zdravljenju mnogih kožnih in podkožnih tumorjev, ploščato celičnega karcinoma glave in vratu, bazalioma, malignega melanoma, adenokarcinomov in Kaposijevega sarkoma. Veliko študij je bilo opravljenih na bolnikih z malignim melanomom. Rezultati so obetavni, saj je popolnih odgovorov na elektrokemoterapijo z bleomicinom kot tudi s cisplatinom več kor 80%. Elektrokemoterapija nakazuje nov pristop k zdravljenju kožnih zasevkov malignega melanoma z uporabo električnih pulzov kot načina dostavljanja citostatikov v celice. | |
| Descriptors | MELANOMA BLEOMYCIN CISPLATIN ELECTRIC STIMULATION THERAPY SKIN NEOPLASMS |