Author/Editor		Glaser, Marjana
Title		Hiperkalcemija pri kronični limfocitni levkemiji
Translated title		Hypercalcaemia in chronic lymphocytic leukemia
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 68, št. 11
Publication year		1999
Volume		str. 633-4
Language		slo
Abstract		Background. Hypercalcaemia is common in some lymphoproliferative diseases like myeloma and T cell chronic lymphocytic leukemia (T KLL). In patients with B cell chronic lymphocytic leukemia (B KLL) hypercalcaemia is described in only few patients. Our patients. We represent two patients with B KLL and hypercalcaemia. Conclusions. Hypercalcaemia is a rare complication of B KLL. Pathophysiologically it is attributed to the reaction between leukemia cells and osteoblasts. Malignant cells secrete local cytokines which stimulate osteoclasts. As a result, bone resorptions and hypercalcaemia appear. Rehidration and bisphosphonates normalise the calcium level, but have no influence on progress of the disease.
Summary		Izhodišča. Hiperkalcemija je simptom, ki se pojavlja pogosteje pri nekaterih napredovalih limfoproliferativnih boleznih kot diseminirani plazmocitom in T-celična kronična limfocitna levkemija. Do sedaj je opisanih le nekaj bolnikov z B-celično kronično limfocitno levkemijo (B KLL) in hi- perkalcemijo. Naši bolniki. Predstavljamo 2 bolnika z napredovalo B KLL in hiperkalcemijo. Zaključki. Hiperkalcemija je redek zaplet B KLL, ki nastane zaradi lokalne razrasti neoplazme v kosteh ali zvečane aktivnosti osteoklastov. Rakaste celice izločajo citokine, ki povečajo aktivnost osteoklastov. Posledica tega je resorpcija kosti in hiperkalcemija. Zdravimo lahko z zdravili, ki normalizirajo serumski kalcij, pri tem pa ne vplivajo na potek osnovne bolezni.
Descriptors		HYPERCALCEMIA LEUKEMIA, LYMPHOCYTIC, CHRONIC CALCIUM OSTEOCLASTS SLOVENIA CYTOKINES