Author/Editor		Arnol, Miha; Vizjak, Alenka; Jurčić, Vesna; Perković, Tatjana; Ferluga, Dušan
Title		Cell adhesion molecules on endothelial cells of kidney and choroid plexus in systemic lupus erythematosus: authopsy study
Type		članek
Source		In: Vizjak A, Rozman B, Ferluga D, editors. Autoimmune systemic diseases. Proceedings of the 30th memorial meeting for professor Janez Plečnik; 1999 Dec 2-3; Ljubljana. Ljubljana: Faculty of medicine, Institute of pathology,
Publication year		1999
Volume		str. 62-6
Language		eng
Abstract		Cell adhesion molecules (CAM) and their ligands have important role in leucocyte extravasation and development of tissue inflammatory inFltrates, including those in systemic lupus erythematosus (SLE). In contrast to kidney, where inflammatory response in the form of different types of lupus nephritis is frequently seen, the inflammation is usually absent in choroid plexus. This difference could be result of different regional expression of CAM on endothelial cells. Expression of endothelial CAM (ICAM-1, VCAM-1 and E- selectin) was investigated in authopsy kidney and choroid plexus tissue samples of SLE patients and compared with expression in normal tissue and with intensity of pathohistological changes. The expression of CAM in kidneys of SLE patients was statistically significantly upregulated on most investigated vascular segments. The CAM expression in choroid plexus was mostly not statistically significantly upregulated and was, in comparison with the kidney expression, less intensive and similar to the pattern seen in normal choroid plexus. The intensity of ICAM-1 expression on endothelial cells of glomerular capillaries correlated with the Activity Index of lupus nephritis. This correlation was less clear for VCAM-1 and E-selectin. The intensity of immune deposits in choroid plexus showed no correlation with intensity of endothelial CAM expression. The results show that the expression of CAM on endothelial cells in the kidney of SLE patients is upregulated when compared with normal kidney. This points to an important role of CAM in transmigration of in*lammatory cells and inflammatory response. Expression of CAM on endothelial cells of choroid plexus in SLE is not upregulated and is less intensive then in kidney, which can explain the absence of inflammatory reaction. In SLE patients intensity of pathohistological changes in kidney correlate to some extent with intensity of endothelial CAM expression, but this is not the case in choroid plexus.
Descriptors		CELL ADHESION MOLECULES LUPUS ERYTHEMATOSUS, SYSTEMIC LUPUS NEPHRITIS CHOROID PLEXUS KIDNEY MICROSCOPY, ELECTRON FLUORESCENT ANTIBODY TECHNIQUE SLOVENIA AUTOPSY