Author/Editor		Jeruc, J; Jurčić, V; Vizjak, A; Hvala, A; Kveder, R; Praprotnik, S; Ferluga, D
Title		Tubulo-interstitial involvement in various WHO classes of lupus nephritis
Type		članek
Source		In: Vizjak A, Rozman B, Ferluga D, editors. Autoimmune systemic diseases. Proceedings of the 30th memorial meeting for professor Janez Plečnik; 1999 Dec 2-3; Ljubljana. Ljubljana: Faculty of medicine, Institute of pathology,
Publication year		1999
Volume		str. 94-8
Language		eng
Abstract		Glomerular lesions in lupus nephritis (LN) are extensively studied, important for classification and prognosis of disease. LN is also a prototype of glomerulonephritis mediated by immune complexes. Much less attention has been given to the tubulo-interstitial compartment. The aim of the study was to contribute to the understanding of the pathogenesis of tubulo-interstitial lesions in LN by analysing their character, incidence, association with glomerular (esions and influence on rena( function. Hundred and ninety kidney biopsies of l90 patients fu(filling ARA criteria of SLE were examined by traditional light, immunoftuorescence and electron microscopy. Additionally, a monoclonal antibodies (DAKO) identifying interstitial CD4SRO (T lymphocytes), CD4SRA (B lymphocytes) and CD6B (macrophages) positive cells were used for immunohistochemical analysis in 52 biopsies and antibodies identifying antigene presenting cells (CDla, S100) itt 28 biopsies. Intentitial volume was measured by point-counting methodology using an int*e analysis system in 28 biopsies. Interstitial inflammatory infittratc (ICI) was found in l29 (67.9'/o) and tubulo-interstitial immune deposits (TID) in 102 (53.7"/o) biopsies, with their simultaneous p*ae * 72 (37.9"/o) oases. Both ICI and TID were the most frequent in WHO ctass IV. ICI was more frequent in cases with TID (p<0.01, by chi-square test). flowever, by multivariatc analysis, the intcnsity of TID correlated the best with the intensity of gtomerular ID, the intensity of gtomerular proliferation, and the presence of "wire-loop" lesions, glomerular cxudation and necrosis. The intensity of ICI correlated the best with the percentage of renal corpuscutes with extracapiltary crescents and extent of interstitial fibrosis. (Abstract truncated at 2000 characters).
Descriptors		LUPUS NEPHRITIS KIDNEY GLOMERULUS MICROSCOPY, ELECTRON FLUORESCENT ANTIBODY TECHNIQUE KIDNEY TUBULES SLOVENIA LEUKOCYTES, MONONUCLEAR WORLD HEALTH ORGANIZATION