Author/Editor		Malovrh, Petra; Sepčić, Kristina; Turk, Tom; Maček, Peter
Title		Characterization of hemolytic activity of 3-alkylpyridinium polymers from the marine sponge Reneira sarai
Type		članek
Source		COMP BIOCHEM PHYSIOL C
Vol. and No.		Letnik 124
Publication year		1999
Volume		str. 221-6
Language		eng
Abstract		Polymeric alkylpyridinium salts (poly-APS) isolated from the marine sponge Reniera sarai act as potent anticholinesterase agents; in addition they show moderate hemolytic and cytotoxic activities. The hemolytic activity of poly-APS is due to their detergent-like structure and behavior in aqueous solutions. In this work, the hemolytic activity of poly-APS is analyzed and compared to that of structurally-related monomeric cationic surfactants. The influence of different divalent cations and lipids on poly-APS induced hemolysis is discussed. The dimensions of lesions caused by poly-APS in erythrocyte membranes are determined by the use of osmotic protectants. Finally, the possible role of poly-APS in their natural environment is proposed.
Descriptors		PYRIDINIUM COMPOUNDS PORIFERA ERYTHROCYTES HEMOLYSIS SURFACE-ACTIVE AGENTS CATIONS