Author/Editor		Maraspin, Vera; Lotrič-Furlan, Stanka; Cimperman, Jože; Ružić-Sabljić, Eva; Strle, Franc
Title		Erythema migrans in the immunocompromised host
Type		članek
Source		Wien Klin Wochenschr
Vol. and No.		Letnik 111, št. 22-23
Publication year		1999
Volume		str. 923-32
Language		eng
Abstract		From 1990 to 1996 a total of 67 adult patients with typical erythema migrans (EM) and a previously identified immunocompromised condition were investigated at the University Medical Centre, Department of Infectious Diseases, Ljubljana, Slovenia. The course and outcome of borrelial infection were compared with 67 previously healthy age and sex-matched individuals with EM who were examined at our institution in the same year. Clinical characteristics of Lyme borreliosi: before treatment and the duration of EM after the institution of therapy with antibiotics including amoxicillin azithromycin, cefuroxime-axetil, doxycycline, and ceftriaxone were comparable in both groups. The occurrence of early disseminated borrelial infection betore treatment and the frequency of treatment failure (defined as the onset of severe minor or major manifestations of Lyme borreliosis, persistence of B. burgdorferi sensu lato in the skin and/or persistence of EM after treatment) were found significantly more often in immunocompromised patients than in the control group (16/67 versus 6/67, respectively; p = 0.0358). Re-treatment was required in 13 (19.4%) patients of the immunocompromised group and only in five (7.5%) patients of the control group (p = 0.0762). However, in spite of the more severe course and the more frequent need for re-treatment among patients whose immune system was impaired, the outcome of borrelial infection after one year was favourable in both groups.
Descriptors		IMMUNOCOMPROMISED HOST ERYTHEMA CHRONICUM MIGRANS ANTIBIOTICS BORRELIA BURGDORFERI LYME DISEASE PENICILLIN V DOXYCYCLINE AZITHROMYCIN AMOXICILLIN CEFUROXIME TREATMENT OUTCOME