Author/Editor		Sollner, M; Pečar, S; Štalc, A
Title		The influence of the lipophilicity of 7-oxoacyl-L-alanyl-D-isoglutamines on their immunorestoration activity in vivo
Type		članek
Source		Eur J Med Chem
Vol. and No.		Letnik 31
Publication year		1996
Volume		str. 927-33
Language		eng
Abstract		In search for immunologically active dipeptides, a series of new N-(7-oxoacyl)-L-alanyl-D-isoglutamines has been synthesized where lipophilicity was varied by changing the 7-oxoacyl residue from 7-oxooctanoyl to 7-oxotetradecanoyl. The immunological properties of the compounds were examined in an in vivo immunorestoration test. It was found that lipophilicity had a significant influence on the potency of the compounds tested. Compounds between N-(7-oxodecanoyl)-L-alanyl-D-isoglutamine and N-(7-oxotetradecanoyl)-L-alanyl-D-isoglutamine showed biphasic influence on efficacy. The most active compound found was 7-oxododecanoyl-L-alanyl-D-isoglutammine, which also has an activity comparable to that of azimexone.
Descriptors		ADJUVANTS, IMMUNOLOGIC ACETYLMURAMYL-ALANYL-ISOGLUTAMINE CYCLOPHOSPHAMIDE CANDIDA ALBICANS MICE