Author/Editor		Dolžan, Vita; Rudolf, Zvonimir; Breskvar, Katja
Title		Genetic polymorphism of xenobiotic metabolising enzymes in Slovenian lung cancer patients
Type		članek
Source		Pflugers Arch
Vol. and No.		Letnik 439, št. 3 Suppl
Publication year		2000
Volume		str. R29-30
Language		eng
Abstract		Most carcinogenic substances require metabolic activation in order to become ultimate carcinogens. Genetic polymorphism of xenobiotic metabolising enzymes cytochromes P450 may therefore influence human cancer susceptibility. The aim of our study was to investigate if CYP1A1 gene polymorphism contributes to lung cancer susceptibility in Slovenian patients. Two polymorphic sites in CYP1A1 gene were analysed in DNA samples from 100 healthy controls and 199 lung cancer patients using genotyping approach. Our results indicate that CYP1A1 may be one of the factors determining susceptibility to squamous cell carcinoma of lung in Slovenian population. However the frequency of CYP1A1 polymorphisms is too low to be a potentially useful marker of increased lung cancer risk.
Descriptors		LUNG NEOPLASMS POLYMORPHISM (GENETICS) CYTOCHROME P-450 CYP1A1 XENOBIOTICS POLYMERASE CHAIN REACTION