Author/Editor | Peterlin, Borut; Petrovič, Daniel; Zorc, Metka; Keber, Irena | |
Title | Deletion/insertion polymorphism in the angiotension-converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease | |
Type | članek | |
Source | Pflugers Arch | |
Vol. and No. | Letnik 439, št. 3 Suppl | |
Publication year | 2000 | |
Volume | str. R40-1 | |
Language | eng | |
Abstract | The angiotensin-converting enzyme (ACE) plays by degradation of angiotensin I and bradykinin, an important role in modulations of smooth muscle proliferation and vascular tone. Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary heart disease (CHD). We compared the I/D polymorphism in 171 Slovenian CHD patients that were younger than 55 years with 134 healthy control individuals. The DD genotype is associated with a 2.3 - fold increase in the risk for CHD. | |
Descriptors | CORONARY DISEASE PEPTIDYL-DIPEPTIDASE A POLYMORPHISM (GENETICS) RISK FACTORS |