Author/Editor     Peterlin, Borut; Petrovič, Daniel; Zorc, Metka; Keber, Irena
Title     Deletion/insertion polymorphism in the angiotension-converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease
Type     članek
Source     Pflugers Arch
Vol. and No.     Letnik 439, št. 3 Suppl
Publication year     2000
Volume     str. R40-1
Language     eng
Abstract     The angiotensin-converting enzyme (ACE) plays by degradation of angiotensin I and bradykinin, an important role in modulations of smooth muscle proliferation and vascular tone. Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary heart disease (CHD). We compared the I/D polymorphism in 171 Slovenian CHD patients that were younger than 55 years with 134 healthy control individuals. The DD genotype is associated with a 2.3 - fold increase in the risk for CHD.
Descriptors     CORONARY DISEASE
PEPTIDYL-DIPEPTIDASE A
POLYMORPHISM (GENETICS)
RISK FACTORS