Author/Editor		Kruljc, P
Title		Primer vpliva fenilbutazona na endotoksemijo in klinično sliko zapleta jejunuma pri konju
Translated title		An example of the influence of phenylbutazone on endotoxemia and the clinical picture of jejunal complications in horses
Type		članek
Source		Zb Vet Fak Univ Ljublj
Vol. and No.		Letnik 36, št. 2
Publication year		1999
Volume		str. 227-33
Language		slo
Abstract		During a clinical examination of a stallion on the day after a race, symptoms were established that could not be logically connected, so a more extensive examination and treatment at our clinic were proposed. A blood sample showed changed blood parameter values. The stallion was brought to the clinic five hours later. On the basis of the clinical picture, intestinal complications were suspected, but the house's condition did not improve even after an opioid analgesic and supportive therapy were administered. The stallion died only one hour after arriving at the clinic. The pathological, histological and toxicological examination showed complications: jejunal necrosis and ulcer, pulmonary edema and a dilated heart, the failure of which was the immediate cause of the horse's death. Toxicological analysis showed the presence of phenylbutazone in the blood. This masked the clinical picture of endotoxemia which had a decisive effect on the damage to the heart and its failure. Immediately before arriving at our clinic, the stallion also received an infusion of calcium preparations, which had an additional toxic effect on the already weakened heart.
Summary		Pri kliničnem pregledu žrebca smo dan po tekmovanju ugotovili simptome, ki jih med seboj ni bilo mogoče logično povezati, zato smo predlagali obsežnejši pregled in zdravljenje na naši kliniki. Odvzeti krvni vzorec je pokazal sprememnjene vrednosti krvnih parametrov. Pet ur kaksneje je bil žrebec pripeljan na kliniko. Na podlagi klinične slike smo posumili na zaplet črevesa, vendar se stanje kljub danemu opioidnemu analgetiku in terapiji ni izboljšalo. Žrebec je poginil le uro po prihodu na kliniko. Patološka, histološka in tokrikološka preiskava je pokazala zaplet jejunuma z nekrozo in čiri, edem pljuč in razširjeno srce, katerega odpoved delovanja je bila neposredni vzrok pogina. Tokrikološka analiza je v krvi dokazala fenilbutazon. Le-ta je zakril klinično sliko endotoksemije, ki je odločilno vplivala na okvaro in odpoved delovanja srca. Tik pred prihodom na kliniko je žrebec z infuzijo prejel še kalcijeve pripravke, kar je učinkovalo negativno na že prizadeto srce.
Descriptors		PHENYLBUTAZONE JEJUNAL DISEASES INTESTINAL PERFORATION HORSES