Author/Editor		Majdič, G
Title		Samec ali samica - sesalska dilema: (Razvoj spola pri sesalcih)
Type		članek
Source		Zb Vet Fak Univ Ljublj
Vol. and No.		Letnik 36, št. 1
Publication year		1999
Volume		str. 121-7
Language		slo
Abstract		Sexual differentiation is one of the most important questions in embryology. In mammals sexual differentiation is strictly chromosomally regulated. Y chromosome carries a dominant gene called Sry, which trigger testis development in the male foetus and the testis subsequently induces the development of the male phenotype while in the absence of the testis, foetus develops as a female. Foetal testis produce several different hormones, of which the most important are steroid hormones testosterone, responsible for development of male secondary sexual organs, and antim(llerian hormone, responsible for muellerian ducts regression. Several other genes are involved in the pathways that lead to sexual differentiation and gonadal development. Among these, SF-1, DAX-1, SOX9 and WT-1 are extremely important although we still do not know their exact roles in the processes of gonadal development.
Summary		Razvoj spola je eno najpomebnejših vprašanj v embriologiji. Pri sesalcih ga urejajo spolni kromosomi, in sicer nosi kromosom Y dominanten gen sry, ki v organizmu sproži razvoj mod. Ta nato spodbudi razvoj celotnega moškega fenotipa, če pa mod ni, zarodek razvije ženski fenotip. Zarodkovo modo izloča številne hormone, med katerimi sta najpomembnejša steroidni hormon testosteron, odgovoren za razvoj sekundarnih moških spolnih organov, in antimuellerjev hormon, ki je odgovoren za propad zametkov za ženske sekundarne spolne organe. Pri razvoju spolnih žlez in posledično moškega ali ženskega fenotipa pa sodelujejo še številni drugi geni. Med njimi so najpomembnejši steroidogeni faktor-1 (SF-1), DAX-1, SOX9 in WT- 1, katerih natančne vloge v razvoju spolnega sistema še ne poznamo.
Descriptors		MAMMALS SEX DIFFERENTIATION SEX CHARACTERISTICS GENITALIA PHENOTYPE TESTOSTERONE Y CHROMOSOME X CHROMOSOME