Author/Editor		Žvan, Bojana
Title		Vpliv sistemske stimulacije simpatičnega živčevja na hitrost krvi v srednjih možganskih arterijah pri bolnikih s sladkorno boleznijo
Translated title		Influence of the systemic stimulation of the sympathetic nervous system on the middle cerebry artery blood flow velocity in patients with diabetes mellitus
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1999
Volume		str. 94
Language		slo
Abstract		Introduction. One of the causes that affect the autonomous nervous system is diabetes mellitus. It is reported disorders in the regulation of cerebral circulation in pateints with diabetes, and therefore this study was aimed to assess the influence of the sympathetic nervous system on Vm in patients with a generalized damage of the autonomous nervous system as well as in those without evidence of such damage. Further, it was also studied the influence of systemic factors on vm changes during sympathetic nerve stimulation in healthy controls and in patients with diabetes. Patients and methods. In a group of 20 healthy volunteers of both genders (age 48 +- 6.8 yrs), agroup of 20 patients of both geneders (aged 51 +- 12 yrs) with diabetes type I or II treated with insulin and pathological findings on cardiocirculatory tests of the autonomous nerves and/or clinical evidence of autonomous neuropathy (group A), in whom diabetes was present for 18.3 years and 20 patients of both genders (age 49 +- 10 yrs) with type I or II diabetes treated with insulin and without clinical or laboratory evidence of autonomous or peripheral neuropathy (group B) and 11.8 year history of diabetes vm was measured in both middle cerebral arteries with TCD. MAP was monitored by means of Finapres, while HR was measured with an electrocardiograph, and Et-CO2 with an infrared caphnograph. Five-minute measurement of all the parameters at rest was followed by the evaluation of vm, MAP, HR and Et-CO2 during a 3-minute CPT, and then again during a 5-minute rest interval, which was followed by measurement during a 5-minute HUT. To analyze the value of variables during rest and stimulation within the groups, we used the paired t-test, while the differences between the variables in different groups were tested by Student's t-test. (Abstract truncated at 2000 characters).
Descriptors		DIABETIC NEPHROPATHIES SYMPATHETIC NERVOUS SYSTEM CEREBRAL ARTERIES BLOOD FLOW VELOCITY MIDDLE AGE DIABETES MELLITUS ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL HEART RATE BLOOD PRESSURE ELECTROCARDIOGRAPHY CAPNOGRAPHY