Author/Editor		Grobovšek-Opara, Sonja
Title		Vpliv zdravil na tveganje zbolevanja za jetrno cirozo
Translated title		Impact of drugs on the morbidity risk of liver cirrhosis
Type		članek
Source		Zdrav Vars
Vol. and No.		Letnik 38, št. 11-12
Publication year		1999
Volume		str. 393-8
Language		slo
Abstract		Starting-points. Numerous chronic liver diseases, and among them also liver cirrhosis, can be attributed to drugs. Presented results of the research on the impact of alcohol, nutrition and drugs on the morbidity risk owing to liver cirrhosis show the degree of connectedness of drug consumption with teh onset of liver cirrhosis. Methods. Research was a study of cases with controls which 182 included newly diagnosed patients with liver cirrhosis on departments for internal diseases of Slovenian hospitals during the period from January to July 1995. Liver cirrhosis was diagnosed on the base of clinical picture, corresponding laboratory results and ultrasound examination. Control persons were inhabitants of Slovenia, matched with patients by sex, age and permanent residence. Data were collected by interview in person. In variate and multivariate data analysis, the method of conditional logistic regression was used. Drugs were divided into four groups.. The first group the known hepatotoxic drugs and the other three groups included sex hormons, vitamins and other drugs. Results. A greater consumption of hepatotoxic drugs and vitamins was found in patients, while there were no significant differences between patients and control persons as far as consuming sex hormons and other drugs is concerned. The number of persons consuming vitamin vitamin preparation was small and was not reliably connected with the onset of liver cirrhosis in the multivariate analysis. The following hepatotoxic drugs: methyldopa, papaverine, propylthiouracil, sulfonamides, phenofibrate, paracetamol, acetylsaliclyc acid, isoniazid, tolbutamide, haloperidol, retinol and amiodarone hydrochloride were consumed in greater number by patients than by control persons. (Abstract truncated at 2000 characters).
Summary		Izhodišča. Številne kronične bolezni jeter, med njimi tudi jetrno cirozo, lahko pripišemo zdravilom. Prikazani rezultati raziskave o vplivu alkohola, prehrane in zdravil na tveganje zbolevanja zaradi jetrne ciroze kažejo, kolikšna je povezanost uživanja zdravil z nzastnakom jetrne ciroze. Metode. Raziskava je bila študija primerov s kontrolami, v kateri smo kot primere zajeli 182 novoodkritih bolnikov z jetrno cirozo na internih oddelkih slovenskih bolnišnic v obdobju od januarja do julija leta 1995. Jetrna ciroza je bila ugotovljena na osnovi klinične slike, ustreznih laboratorijskih izvidov in ultrazvočne preiskave. Kontrolne osebe so bili prebivalci Slovenije, usklajeni z bolniki po spolu, starosti in kraju stalnega bivališča. Podatke smo zbrali z osebnim intervjujem. V univariatni in multivariatni analizi podatkov smo uporabljali metodo pogojne logistične regresije. Zdravila smo razdelili v štiri skupine. V prvi skupini so bila znana hepatotoksična zdravila, posebej pa smo prikazali še spolne hormone, vitamine in ostala zdravila. Rezultati. Pri bolnikih smo ugotovili večjo porabo hepatotoksičnih zdravil in vitaminov, pri jemanju spolnih hormonov in ostalih zdravil pa ni bilo značilnih razlik med bolniki in kontrolnimi osebami. Število oseb, ki je jemalo vitaminske preparate, je bilo majhno in v multivariatni analizi uživanje vitaminov ni bilo zanesljivo povezano z nastankom jetrne ciroze. Bolniki so v večjem odstotku kot kontrolne osebe jemali naslednja hepatotoksična zdravila: metildopa, papaverin, propiltiouracil, sulfonamide, fenofibrat, paracetamol, acetilsalicilno kislino, izoniazid, tolbutamid, haloperidol, retinol in amiodaron. Osebe, ki so uživale navedena zdravila so imele 5,2-krat večje tveganje (IZ 2,2-12,7) za nastanek jetrne ciroze v primerjavi z osebami, ki teh zdravil niso uživale. (Izvleček je prekinjen pri 2000 znakih).
Descriptors		LIVER CIRRHOSIS RISK FACTORS CASE-CONTROL STUDIES ACETAMINOPHEN ASPIRIN VITAMINS SEX HORMONES