Author/Editor     Novak-Antolič, Živa; Logar, Jernej; Zore, Andrej; Cerar, Vasilij; Kraut, Aleksandra; Frelih, Jana
Title     Presejanje nosečnic na toksoplazmozo v Sloveniji: predpisi in njihovo izvajanje ter vpliv na zmanjševanje posledic pri otroku in kasneje v življenju
Type     članek
Source     In: Bregant L, editor. Zbornik referatov Nebakterijske okužbe v perinatologiji; 1998 maj 8-9; Ljubljana. Ljubljana: Društvo za pomoč prezgodaj rojenim otrokom,
Publication year     1998
Volume     str. 130-7
Language     slo
Abstract     In slovenian literature there are articles about congenital toxoplasmosis since 1953. In 1981 screening for pregnant women for primoinfection in pregnancy was introduced, which is obligatory by law since 1995. At preconceptional gynecological visit, when we subscribe folic acid, we check if IgG antibodies for toxoplasmosis were already determined in the past. If they were positive, no more testing is necessary. If they were negative, testing should be done very early in pregnancy, in 20. week of pregnancy and one month before expected date of delivery. Pregnant women to be should be educated about prophylactic measures against infection in pregnancy. Screening should be done with cheapest most appropriate tests. Seroconversion means primoinfection. When titers of IgG antibodies are high or had risen many times, other antibodies (IgM, IgA) and avidity of IgG antibodies should be determined to be able to estimate when the infection occurred. In some cases cordocentesis is indicated to assess fetal antibodies and PCR from amniotic fluid. When primoinfection is proven, therapy (spiramycin, pirimetamin and sulphadiazin after 20. week of pregnancy) is indicated, very rarely in early pregnancy termination of pregnancy is advised. Acute infection should be reported. When primoinfection is suspected, therapy is also advised. Newborns of these mothers should be given spiramycin until diagnosis is proven or rejected. They should be entered in the register and follow-up visits should be done regularly. When disease, which could be etiologically connected to congenital toxoplasmosis, is discovered later in life, appropriate therapy is mandatory as well as reporting. We advise that registry for toxoplasmosis be instituted at the Institute of public health to surveil the effectiveness of screening. (Abstract truncated at 2000 characters.)
Descriptors     PREGNANCY COMPLICATIONS, PARASITIC
TOXOPLASMOSIS
PREGNANCY
SERODIAGNOSIS
IGG
MASS SCREENING