Author/Editor		Kranjec, Igor; Černe, Andreja
Title		Vascular complications after percutaneous coronary interventions using abciximab (Reopro TM): prospective evaluation with Doppler color flow imaging
Type		članek
Source		J Invasive Cardiol
Vol. and No.		Letnik 12, št. 2
Publication year		2000
Volume		str. 86-94
Language		eng
Abstract		The aim of our study was to assess the incidence and consequences of vascular access site complications (VASC) associated with abciximab treatment in patients undergoing percutaneous transluminal coronary angioplasty (PTCA). Patients and Methods. Between July 1996 and November 1997,120 patients underwent PTCA with adjunctive abciximab (n = 60) or without it (n = 60). VASC were assessed within 24 hours of PTCA completion by physical examination and Doppler color flow imaging (DCFI) of the groin. Results. A total of 24 VASC were observed mostly in abciximab patients (30% vs.10% p =0.006) and only half of them were suspected on physical examination. Abciximab administration (odds ratio (OR) = 3.1; 95% confidence interval (CI) =1.03-9.0; p = 0.001), platelet fall > 40% (OR = 5.0; CI =1.03-24.6; p = 0.045), and double-wall femoral artery puncture (OR = 5.3; CI =1.9-14.7; p = 0.001) carried a high probability of VASC after multivariate analysis. Vascular repair was needed in 10% of abciximab patients. Conclusions. Aggressive antiplatelet drugs adjunctive to the anticoagulation treatment may result in an increased rate of VASC after PTCA. The use of refined catheterization techniques is advised to avoid VASC associated with abciximab administration. DCFI is recommended in the patients with abnormal groin finding or significant platelet fall after PTCA.
Descriptors		ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY CORONARY DISEASE ULTRASONOGRAPHY, DOPPLER, COLOR PHYSICAL EXAMINATION ERYTHROCYTE COUNT PLATELET COUNT CATHETERIZATION, PERIPHERAL PLATELET AGGREGATION INHIBITORS ANTICOAGULANTS HEMORRHAGE