Author/Editor     Gorenjak, M
Title     Presejalni testi za celiakijo - naše izkušnje
Translated title     Screening tests for coeliac disease - our experience
Type     članek
Source     Slov Pediatr
Vol. and No.     Letnik 7, št. Suppl 1
Publication year     2000
Volume     str. 72-4
Language     slo
Abstract     The assessment of serum antibodies is a significant factor in diagnosing coeliac disease. The oldest and most valued methods of determining antigliadin antibodies IgG and IgA were supplemented by investigations of antiendomysial antibudies IgA, in combination with antigliadin antibodies representing a very specific and sensitive combination of serologic tests. The inclusion of antigliadin, antireticulin and antiendomysial antibodies in the ESPGAN criteria has changed this type of diagnosis into a routine laboratory procedure. Antibodies against tissue transglutaminase, representing a veritable antigen structure of the endomysium, are still in development and their actual diagnostic value remains unelucidated. Despite the nonspeciticity of antigliadin antibodies IgG, their assessment is still justified by their excellent sensitivity.
Summary     Določanje serumskih protiteles predstavlja v diagnostiki celiakije pomemben dejavnik. Najstarejša in uveljavljena določanja antigliadinskih protiteles IgG in IgA so dopolnile preiskave antiendomizijskih protiteles IgA, ki predstavljajo v kombinaciji z antigliadinskimi protitelesi zelo specifično in občutljivo kombinacijo seroloških testov. Vključitev antigliadinskih, antiretikulinskih in antiendomizijskih protiteles v merila ESPGAN kriterije je tovrstno diagnostiko spremenilo v rutinsko dejavnost laboratorijev. Za protitelesa proti tkivni transglutaminazi, ki predstavlja pravo antigensko strukturo endomizija, šele spoznavamo diagnostični pomen. Kljub nespecifčnosti antigliadinskih protiteles IgG je njihovo določanje še vedno smiselno zaradi njihove občutljivosti.
Descriptors     CELIAC DISEASE
MASS SCREENING
IGG
GLIADIN
REAGENT KITS, DIAGNOSTIC
CHILD
IGA