Author/Editor		Mivšek-Mušič, E; Mušič, P
Title		Kako ravnamo ob domnevi alergije na beta-laktamske antibiotike
Translated title		The management of patients with suspect allergy to beta-lactam antibiotics
Type		članek
Source		Slov Pediatr
Vol. and No.		Letnik 7, št. Suppl 1
Publication year		2000
Volume		str. 152-5
Language		slo
Abstract		Different mechanisms are involved in allergic reactions to penicillins and other B-lactam antibiotics, which are expressed as skin rush, systemic reactions and also life-threatening anaphylaxis. Sensibilisation to penicillins is not present lifelong. In the article the incidence of allergic reactions to penicillins and other B-lactams is presented. Clinical manifestations of allergy are described and the time relationship from the application of the drug to the onset of symptoms is emphasised. The onset of the most dangerous systemic reactions is within the first hour. The differential diagnosis is also described. Suggestions for dealing with patients allergic to penicillins or cephalosporins in case of indication for antibiotic treatment are given as well.
Summary		Alergijske reakcije za peniciline in druge B-laktamske antibiotike potekajo po različnih mehanizmih. Izražajo se kot kožni izpuščaji, kot sistemske reakcije, lahko tudi kot nevarna stopnja anafilakse. Senzibilizacija za peniciline v organizmu ni statično dejstvo za vse življenje. Članek navaja podatke o pogostnosti alergije za peniciline in druge B-laktamske antibiotike. Opisane so klinične oblike alergije, poudarek je na časovnem odnosu od dajanja zdravila do dogodka. Najnevarnejše so sistemske reakcije, ki nastopijo v prvi uri. Naštete so tudi možnosti pojavov za diferencialno diagnozo. Podani so nasveti, kako bolnika z domnevo ali dokazom alergije za peniciline varno obravnavamo in tudi, kako ga zdravi v primeru indikacije za antibiotik.
Descriptors		ANTIBIOTICS, LACTAM DRUG HYPERSENSITIVITY CHILD PENICILLINS AMPICILLIN CEPHALOSPORINS