Author/Editor		Homšak, M; Brunčko, A; Skerbinjek-Kavalar, M
Title		Klinična slika alergije na zdravila
Translated title		Clinical picture in drug allergy
Type		članek
Source		Slov Pediatr
Vol. and No.		Letnik 7, št. Suppl 1
Publication year		2000
Volume		str. 159-62
Language		slo
Abstract		Adverse drug reactions often occur in children treated with specific drugs. In children, the clinical picture is most frequently expressed by skin affection, more rarely by systemic reaction or affection of other organs. It is almost impossible to differentiate the individual types of adverse drug reactions on the basis of the clinical picture. We should keep in mind that of all adverse drug reactions merely 6-10% are actually allergic reactions. In allergic reactions, it is extremely difficult to confirm the immunologic mechanism representing the pathophysiologic basis. Only knowledge of the pathophysiologic mechanism can serve as basis for an adequate diagnostic procedure. The paper contains a precise description of the most frequent clinical pictures in children with allergic drug reactions. description includes alterations on the skin and other organs as well as the occurrence of anaphylaxis. The substances most frequently causing the statued changes are also mentioned. Diagnosis and therapy are described in other papers.
Summary		Neželene reakcije na zdravila se pogosto pojavljajo pri otrocih, ki se zdravijo z določenimi zdravili. Najpogosteje se klinična slika pri otrocih izraža s prizadetostjo kože, redko pa so prisotne sistemske reakcije in prizadetost drugih organov. Ločevanje neželenih reakcij na zdravila na posamezne tipe je s klinično sliko skoraj nemogoče. Zavedati se moramo, da je od vseh neželenih reakcij na zdravila resnično alergijskih le 6-10%. Zelo težko pri alergijskih reakcijah potrdimo imunski mehanizem, ki predstavlja patofiziološko osnovo. Šele s spoznavo patofiziološkega mehanizma namreč lahko načrtujemo ustrezno diagnostiko. V članku so natančneje opisane najpogostejše klinične slike ob alergijskih reakcijah na zdravila pri otrocih. Opisi vsebujejo spremembe na koži, drugih organih in pojav anafilaksije. Omenjene so najpogostejše substance, ki opisane pojave povzročijo. Diagnostika in zdravljenje so opisani v drugih prispevkih.
Descriptors		DRUG HYPERSENSITIVITY CHILD